Ukraine Offers

TODENZE-Opening the pathway towards dendritic zeolites

Spain

IMDEA Energy Institute Mostoles

David Serrano

Postdoc postdoc with experience in drug/gene carriers Co-encapsulation of antitumoral drugs and RNA therapeutics molecules in dendritic zeolites.
Evaluation of the encapsulation success by means of state-of-art techniques
Investigation of the biosafety and efficacy in diverse tumor lines.

TOMATTO-The ultimate Time scale in Organic Molecular opto-electronics, the ATTOsecond

Spain

Autonomous University of Madrid Madrid

Fernando Martin

Postdoc Theoretical modelling of ultrafast phenomena The group of Fernando Martín (https://campusys.qui.uam.es/ at Universidad Autónoma de Madrid and IMDEA Nanoscience, is looking for a researcher to work in an ERC funded project seeking to capture ultrafast electron dynamics to enhance solar energy conversion efficiency.
Position requirements
- A PhD in theoretical chemistry, AMO Physics or related areas.
- Experience in advanced computational modelling
- Experience in scientific programming languages (e.g., Fortran 90, C, C++, Python, etc)
- Advanced knowledge of atomic and molecular physics
- Good oral and written proficiency in English
- Ability to work both independently and as part of a team

cofacTau-Cofactors at the core of tau prion behaviour

France

National Centre for Scientific Research (CNRS) Bordeaux

Yann Fichou

PhD student The tau protein is an intrinsically disordered protein present in the brain where it regulates the microtubule activity. Tau is directly implicated in several neurodegenerative diseases, including Alzheimer's disease. In these diseases, called tauopathies, tau aggregates into so-called amyloid filaments, which are deleterious for the survival of neurons and can spread throughout the brain. Our group studies the formation of these aggregates and more generally the molecular basis of tauopathies.

This project aims at studying the mechanisms of tau protein aggregation induced by different co-factors. In particular, we are interested in the molecular factors that allow the seeding and structural templating of these amyloids. During this thesis, the candidate will (i) extract and characterize aggregates from brain tissue (ii) express and purify recombinant tau protein (iii) perform in vitro seeding assays, under different conditions mimicking biological environments and (iv) perform biophysical and structural characterizations. This multidisciplinary project will combine biochemical techniques with fluorescence spectrometry, infrared spectroscopy, magnetic resonance spectroscopy, atomic force microscopy and cryo-electron microscopy. This thesis, funded by an ERC project and the Fondation Vaincre Alzheimer, will be carried out in a interdisciplinary context involving several national and international collaborations.
You are motivated and curious and you wish to discover a modern and dynamic research environment through this PhD project. You have demonstrated excellent results in a biology/biochemistry/biophysics/physical-chemistry background with an interest in molecular sciences. You like multidisciplinary approaches and you have the ability to work in a team. You wish to discover biophysical methods and apply your skills to better understand fundamental pathological mechanisms. A good level of spoken and written English is essential.
The thesis will take place at the CBMN Laboratory (UMR5248) in the team of Y. Fichou, located at the European Institute of Chemistry and Biology (IECB) near Bordeaux. The IECB is a multidisciplinary institute at the interface of biology and chemistry, and is equipped with several platforms (biochemistry, bacteriology, crystallography/X-ray diffraction, NMR, mass spectrometry, electron microscopy) that will be accessible during the thesis project.
The beginning of the thesis is expected for September 2023. Please address any inquiry to Dr. Yann Fichou (y.fichou@iecb.u-bordeaux.fr) and send your CV, a cover letter, a recommendation letter and you master’s transcripts for application.

MULTIPLEX-Multidimensional interferometric photoelectron spectroscopy with extreme ultraviolet photons

Germany

University of Freiburg Freiburg

Lukas Bruder

PhD student MSc or comparable degree in physics, chemistry or optical engineering is required Understanding photochemical processes in individual molecules remains a major challenge due to the involved non-adiabatic coupling between electronic and vibrational degrees of freedom and the ultrafast time scales of the molecular dynamics. We will address this challenge with a new experi-mental approach combining state-of-the-art techniques: tabletop XUV photoelectron spectroscopy with ultrafast interferometric and multidimensional spectroscopy. As a unique feature, this approach will provide a gap-less mapping of molecular dynamics along the entire reaction coordinate and re-solve the dynamics with unprecedented spectro-temporal resolution.

The PhD candidate will join a small team of highly motivated researchers in the group of Lukas Bruder at the University of Freiburg, Germany. The team will build the new experimental apparatus and investigate prototypical photo-driven reactions ranging from isomerization reactions to intra/inter-molecular energy and charge transfer processes. Depending on the candidate’s preferences the PhD project will have a main focus on laser engineering and nonlinear optics; the development of the XUV beamline; building the molecular beam machine for sample preparation including the photoelectron/-ion detection.

The PhD project will be embedded in the graduate school www.rtg-dyncam.de which provides an outstanding environment for the research and career development of the doctoral candidate. Applicants should have strong interest in atomic and molecular physics or physical chemistry. Experience in the use of ultrafast lasers and/or vacuum equipment is desired. Applications including a letter of motivation, a CV, certificates of your university degree (including grades), a transcript of records and contact details of two references should be sent in a single pdf file by email. Please indicate the subject “PhD MULTIPLEX” in your email.

PURANA-Mythical Discourse and Religious Agency in the Puranic Ecumene

Netherlands

Leiden University Leiden

Peter Bisschop

Postdoc Postdoctoral researcher on literary and material cultures of Southeast Asia https://www.universiteitleiden.nl/vacatures/2023/q1/13516-postdoctoral-researcher-to-focus-on-the-influence-of-the-puraṇas-on-the-literary-and-material-cultur

COMMUNITY-Unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand

Netherlands

Leiden University Leiden

Gilles Van Wezel

PhD student • MSc in Biology, Microbiology, Molecular Biology or similar discipline
• Ability to perform independent research
• Good social and communication skills; excellent scientific writing and presentation skills.
• Proven affinity for systems biology and bioinformatics and a particular interest in global regulatory networks
• Excellent scientific writing and presentation skills
• Team player with strong social skills, dedicated to innovative research combined with scientific curiosity
• Excellent oral and written English communication skills Streptomyces are bacteria commonly found in soils with the capacity to produce a wide range of natural products that we harness for clinical, biotechnological and agricultural applications. Streptomyces bacteria are usually grown in isolation and in laboratory media that do not accurately mimic the complexity of their natural habitat. Primary (carbon) metabolism has a strong impact on specialised metabolism, including antibiotic production. The efficiency of antibiotic production depends a lot on the specific culturing conditions. A key element of this research project is the so-called lab-soil dichotomy, in other words, the large difference between growth of bacteria in the laboratory and in the complex natural habitat. We seek to bridge this huge knowledge gap, and you will investigate the effect of carbon utilization at the transcriptional and metabolic level, in the laboratory and in soil. This will provide better insights into how the bacteria respond to changing nutritional conditions and how we can harness that for the activation of specialised metabolism.
You will apply microbiology and molecular biology techniques, systems biology such as ChIP-seq and Dap-Seq (DNA affinity purification sequencing) to identify the genome-wide distribution of transcription factor (TF) binding sites, transcriptomics etc. Thus you will unravel the TF networks that tie primary to specialised metabolism.

more info: https://www.universiteitleiden.nl/vacatures/2023/kwartaal-1/23-191phd-carbon-control-and-antibiotic-production-in-streptomyces

HOLOVIS-Holographic control of visual circuits

France

Centre National De La Recherche Scientifique Cnrs Paris

Valentina Emiliani

PhD student physicist The aim of this project will be to conceive and realize three-photon excitation (3PE) strategies for all-optical investigation of neuronal circuits in-depth. 3PE uses longer wavelengths that undergo less scattering comparing to two-photon excitation strategies, whilst the cubic power dependence of the excited fluorescence signal to the excitation light intensity further suppresses out-of-focus excitation, enhancing contrast and penetration depth. 3PE microscopy is increasingly used in neurosciences for imaging deep brain layers (down to ~1 mm). Here, we will use it combined to optogenetics for in-depth control of neuronal activity.
The candidate will design, develop and validate a 3PE microscope based on spatiotemporal light-targeting methods developed by our group. With this system, we aim to demonstrate for the first time 3P manipulation of neuronal circuits via optogenetics with the long term prospective of using the system for circuit investigation in primates.

FDC-Finite and Descriptive Combinatorics

United Kingdom

University of Warwick Coventry

Oleg Pikhurko

Visiting researcher There is possibility to support short/medium term visits to the group, for collaborating in various areas of combinatorics related to the project.

SYNCPOL-Synchronised Politics: Multiple Times and Political Power

Germany

University of Munich (LMU) Munich

Klaus Goetz

Postdoc SYNCPOL conceptualises synchronisation arrangements as a critical variable that is fundamental to the distribution of political power amongst policy-makers. It rigorously probes hypotheses on this crucial connection employing a mixed-methods design that combines document analysis, interviews, a major survey, dictionary-based text analysis and process tracing. The project examines synchronisation across EU, national and subnational governments, parliaments and administrative agencies. The analysis covers two policy domains migration-asylum and public health policy – since the early 2010s. SYNCPOL will generate fundamentally new insights into how time shapes democratic multi-level politics and policy.

Candidates for this post are expected to have a doctorate in political science, public policy or public administration completed by the date of appointment; methodological experience with text-as-data; and the ability to work in a team. Subject knowledge in the field of public health represents an advantage. The position is initially limited to three years, with the possibility of extension for another year.

FragMent-Geographic environments, daily activities and stress: a study on the space-time fragmentation of exposure patterns

Luxembourg

ULB Free University of Brussels Esch-Belval

Camille Perchoux

PhD student A Master in a relevant discipline such as geography, public health, epidemiology, data sciences
applied to health, bioinformatics or biostatistics;
Knowledge in quantitative research methods;
Advances skills for data management and statistics;
Experience with Machine learning technics;
Advanced skills for writing scientific peer-review papers in English;
Advanced skills for presenting research results to scientific conferences and to a lay audience;
Skills in French, German or Luxembourgish would be an asset, but not mandatory;
Good organizational skills, good communication skills;
Ability to take own initiatives, as well as a strong ability for teamwork. Geographic environments, daily activities and stress: a study on the space-time fragmentation of
exposure patterns.

Stress is nearly ubiquitous in everyday life, and act as a major risk factor of numerous mental and
physical disorders. The aim of the FragMent project is to evaluate to which extent the spatial and
temporal fragmentation of exposures to environments in daily life influences physiological and
psychological stress, as well as social inequalities in stress.

Engaging in daily activities translates into travelling to and staying within a variety of environments
over a day. Exposures to daily environments may either act as a contributor to stress or provide some
restorative qualities. For example, while greener environments reduce stress, higher built-up density
and proximity to traffic do the reverse. Yet, the combination of these momentary effects on stress over
a day have so far been largely ignored. This project builds on a corpus of evidence from neighborhood
effect in epidemiology, and creates a bridge with the concept of activity fragmentation from Time
Geography, to investigate the determinants of momentary, daily and chronic stress.
Leading the research effort on the identification of vocal biomarkers of stress and examine the
effects of the urban environments and exposure patterns on momentary and daily stress.

This sub-project in FragMent aims to assess the impact of urban environment, exposure patterns and
activity patterns on momentary, daily and chronic stress in daily life. We will rely on an observational
cross-sectional study collecting information on both self-reported psychological stress measurements
and physiological measurements based on vocal biomarkers of stress. Using map-based
questionnaires, this study will collect information of individual’s regular mobility and activity patterns,
to be correlated with chronic stress. In addition, we will make use of Geographically explicit Ecological
Momentary Assessment combining GPS data with repeated assessment of participants’ momentary
stress, activity patterns, and environmental perceptions over 15 days, in order to accurately capture
participants’ activity space.

The successful candidate will be expected to contribute to the FragMent project as described above
and will be in charge of running analyses on the environmental correlates of momentary and daily
stress. An important phase will be the identification of vocal biomarkers of stress using machine
learning methods. To this end, the successfull candidate will be hosted at the Luxembourg Institute of
Health (LIH) to build core knowledge and methods of the identification of vocal biomarkers.