NUCLEAR is a Marie Skłodowska-Curie Action Doctoral Network (MSCA-DN) funded by the European Commission under the Horizon Europe program. This initiative aims to train 17 Doctoral Candidates (DCs) in the emerging field of Metabolic Regulation of Genome Function and Cell Identity, with direct relevance to stem cell biology and cancer research.
The project brings together 14 beneficiary institutions and 12 partner organizations, connecting European leaders in metabolomics, functional genomics, chromatin regulation, stem cell biology, and cancer research with innovators in precision nutrition, mass spectrometry technologies, and drug development.
This project will bring together European leaders in the fields of metabolomics, functional genomics, chromatin regulation, stem cell biology, and cancer with innovators in precision nutrition, mass spectrometry technologies, and drug development. Details of the available research projects are provided in the Nuclear website.
The Nuclear project aims to develop tools for the detection of metabolism in the nucleus, to understand how metabolism regulates functions of the chromatin template and to test metabolism-chromatin interactions as targetable vulnerabilities in cancer cells.
HOW TO APPLY
Please apply for one to a maximum of three individual research projects through the application form below and provide the following information (in English):
Personal details, including your full name, gender, nationality, and contact information.
A curriculum vitae, including academic grades from examination periods (bachelor’s - and master’s if already available), and referees’ contact details.
A motivation letter (up to 2 pages) outlining your research experience, academic accomplishments, and your interest in NUCLEAR and the specific research project. Important: if the DC is applying to more than one position, a motivation letter per project will be required.
Master’s degree certificate or proof that the required degree to be enrolled in a PhD program will be obtained by the time of recruitment if not already awarded.
Please indicate on the application form below the Doctoral Candidate position(s) to which you wish to apply (up to 3). Details of the available research projects are provided in the Nuclear website or by clicking in the title of each individual program.
Doctoral Candidate (DC) position:
DC1: The impact of nuclear NAD levels on transcriptional regulation and DNA repair.
DC2: Impact of nuclear localisation of enzymes on acyl-CoA-mediated PTMs on histone and non-histone proteins.
DC3: Visualizing acyl-CoA and associated metabolites with subcellular resolution To apply for this position, please do it also through this website here. Only applications received in both systems will be considered.
DC4: Investigating the 2-hydrohyglutarate (2-HG) protein interaction network in leukemia cells.
DC5: Computational analysis and modelling of acyl-CoA metabolism and protein acylation dynamics. To apply for this position, please do it also through this website here. Only applications received in both systems will be considered.
DC6: Uncovering the role of nuclear acetyl-CoA metabolism in differentiation. To apply for this position, please do it also through this website here. Only applications received in both systems will be considered.
DC7: Elucidating the impact of metabolite-binding by histone variants in gene regulation and chromatin architecture.
DC8: SCFAs as regulators of cell specification through epigenetic regulation in cancer.
DC9: Metabolic crosstalk and nuclear acetyl-CoA metabolism in the hematopoietic niche.
DC10: Assessment of genetic background in the epigenetic response to metabolites.
DC11: Modulation of NAD+ -dependent PARP1/2 activity on chromatin by regulatory cofactors and impact on cancer.
DC12: A functional genomics approach to assess nuclear essentiality of metabolic enzymes.
DC13: Testing chromatin-bound metabolic enzymes as vulnerabilities in acute myeloid leukemia.
DC14: Metabolites as epigenetic substrates drive myeloid lineage bias in aging individuals and AML.
DC15: The role of histone metabolic reservoirs in liver cancer. To apply for this position, please do it also through this website here. Only applications received in both systems will be considered.
DC17: Nuclear propionyl-CoA as a mediator between nutrition, chromatin regulation and cancer cell proliferation.