MSCA Individual Fellowship / Global Fellowship - Protein and lipidic biomarkers in control of the inflammatory status in parasitic and metabolic diseases

Protein and lipidic biomarkers in control of the inflammatory status in parasitic and metabolic diseases

The project “Protein and lipidic biomarkers in control of the inflammatory status in parasitic and metabolic diseases” includes the essence of the current projects in the Laboratory of Immunobiology of the Inflammation – Labiin. The group investigates protein biomarkers such as cytokines (TNF, IFN-gamma, IL-6, IL-10, IL-22, IL-33, the receptor activator of nuclear factor κB “RANKS” and others), chemokines (CCL2, CCL3, CCL5, CXCL16, CX3CL1, and others) and lipidic mediators (Resolvins, maresins, protectins, prostaglandins, leukotrienes, and others) in the evolutive prognosis of illnesses which “inflammation” is the masterpiece for the pathogenesis. The selected candidate/researcher shall have a well-honed interpersonal capacity and interest in those biomarkers related (i) to the human and/or experimental Trypanosoma cruzi or Toxoplasma gondii infection; (ii) to the nutritional disturbances; (iii) to the effects of the phototherapy; (iv) to the effects of aerobic and strength physical exercises; (iv) to the human pre-eclampsia and (v) to human cancer.

Regardless the background formation of this candidate/researcher, he/she will have the opportunity to learn and experienced the practice in the following aspects: (i) protozoan infection and manipulation with experimental animals, (ii) immunological/histological and molecular methodologies, such as immunoassays, immunocytochemistry, histological preparations and stains, quantitative PCR and others (iii) cellular cultures, to test new chemical compounds with anti-inflammatory and anti-protozoan properties and (iv) following the clinical/nutritional attendances and all the steps beyond (collection and processing of the biological samples, clinical database construction, and laboratory sample analysis.

Labiin team is formed by biologists, nutritionists, physical educators, pharmaceuticals, and medical doctors that will be able to assist and support the researcher during the adaptation period (1-2 months). After that period, it is expected that the candidate is able to integrate the group of researchers and chose 1 (one) or 2 (two) projects to the immersion and effective participation and contribution. Based on his/her previous experience, the candidate shall detect knowledge gaps in the projects, shall propose new comprehensive research strategies and execute them in an adequate methodological context, and to be able to draft-writing or pitch the project for publication, if the time is sufficient. Finally, in parallel to the investigative activities, the candidate/researcher shall also participate and contribute to the discussions in the Labiin weekly-scientific meetings, contribute to the formation of undergraduate and graduate students and propose seminars and/or short-courses to the graduating students of the Health and Nutrition Graduate Program.

Host: Prof.

Andre Talvani Pedrosa da Silva 

E-mail address: 

talvani@ufop.edu.br

CV: 

http://lattes.cnpq.br/3103088504501213

Federal University of Ouro Preto

Universidade Federal de Ouro Preto - Federal University of Ouro Preto (UFOP) is a higher education and research institution located in Minas Gerais State, southeastern Brazil. It was founded on August 21st, 1969, as a consolidation of two significant preexisting institutions:

Escola de Farmácia - School of Pharmacy (1839), the first School of Pharmacy in Latin America, and Escola de Minas - School of Mines (1876), founded by the French mineralogist Henry Gorceix and the first Brazilian institution aimed to teach Mining, Metallurgy, and Geology.

In addition to Escola de Minas and the Escola de Farmácia, UFOP covers all areas of knowledge in 13 academic units, distributed across four campi (located in the cities of Ouro Preto, Mariana, and João Monlevade). The main campus is located in Ouro Preto, a multicultural city with a vast calendar with some of the biggest cultural and artistic events in Brazil. It was the first place in Brazil to be considered by UNESCO as a World Cultural Heritage. UFOP comprises 142 research laboratories (in 2018 its patent number130 was registered), approximately 300 outreach projects (community engagement), 12 libraries (including a rare books library from 18th and 19th centuries), a Center of Arts and Conventions, a Movie Theater, and some museums, as the Museum of Pharmacy and the Museum of Mineralogy.