- JOB
- Switzerland
STATUS: EXPIRED
23 Jan 2025
Job Information
- Organisation/Company
- Societe Des Produits Nestle SA
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Switzerland
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 16 with employment at Nestle Research, Switzerland, www.nestle.com
Interplay of metabolic fluxes between dietary NAD+ precursors Background: Nestlé Research has performed a range of pre-clinical and clinical studies with NAD precursors including a comparative clinical metabolomics study of the NAD metabolome in blood cells of healthy adults, and demonstrated health efficacy of different dietary NAD precursors that are tissue-specific and involve complex metabolic cross-talks. In our research program on the nutritional management of sarcopenia, we have demonstrated that NAD levels are low in skeletal muscle of sarcopenic patients and that trigonelline (a novel NAD precursor) associates with muscle health in humans7. Objectives: (1) Characterize cell type specific uptake and changes of the NAD metabolome in liver, kidney, muscle, and blood cells treated with different dietary NAD precursors (NR, NMN, NAM, trigonelline, tryptophane) (2) Characterization of NAD precursor metabolic fluxes in cells using isotope tracing (HILIC-HRMS). (3) Modelling of metabolic fluxes in the NAD metabolome using cellular data and pre-existing clinical data, and prediction of synergies between NAD precursors and interaction with physiopathology. (4) Validation of combinations of NAD precursors on age-related health benefits using existing lifespan and healthspan assays in C. elegans.
As a PhD candidate at Nestlé Research, supported by a prestigious Marie Skłodowska-Curie fellowship around the hub molecules of life, you will investigate the interplay of metabolic fluxes related to dietary NAD+ precursors. You will perform pre-clinical experiments,conduct metabolomic analyses by high resolution mass spectrometry and apply data modeling approaches to model fluxes and widen our understanding of NAD+ in health and disease. Besides a vibrant scientific experience in an industrial environment, and as part of an EU project, you will collaborate internationally and present the results at scientific meetings and in publications.
A day in the Life of a PhD student at Nestlé Research
• Design and perform preclinical experiments to enhance our understanding of NAD metabolism in health and disease
• Conduct the NAD metabolome by LC-HRMS and investigate fluxes in cells and in vivo systems.
• Model metabolomic fluxes within and across metabolic tissues
• Report and publish the results in scientific journals and present at international meetings
• Collaborate with internal and external research teams
Supervisor: Jerome Feige and Stefan Christen (jerome.feige@rd.nestle.com, stefan.christen@rd.nestle.com )
Link to DC16: HubMOL | UiT
Location: Lausanne, Switzerland
Gross salary: in CHF – 4200/month and calculated for 13 months – makes around 58000 CHF a year
In Euro it would be – 4462/month and calculated for 13 months – makes around 61600 Euro a year.
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- Master’s degree in systems biology, biochemistry or biotechnology
- Programming skills in R or related languages
- Training and experience in LC-MS would be a plus
Specific Requirements
• Master’s degree in systems biology, biochemistry or biotechnology
• Programming skills in R or related languages
• Training and experience in LC-MS would be a plus
• Passion and strong theoretical background in cellular metabolism and health
• Excellent communication skills in English (both written and spoken)
• Scientific creativity, curiosity and strong motivation to solve biological questions
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences
Additional Information
Benefits
- Genuine opportunities for career and personal development
- Modern “smart office” locations providing agile & collaborative workspaces
- Dynamic international working environment
- Attractive additional benefits
Eligibility criteria
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
Selection process
The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions.
The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Societe Des Produits Nestle SA
- Country
- Switzerland
- Geofield
Contact
- Website
- jerome.feige@rd.nestle.comstefan.christen@rd.nestle.com