- JOB
- Netherlands
- EXPIRES SOON
Job Information
- Organisation/Company
- MIMETAS
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Netherlands
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: https://uit.no/research/hubmol
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 14 with employment at MIMETAS, Leiden Netherlands https://www.mimetas.com/en/home/
Liver on-a-chip models for liver metabolic dysregulation research Background: Imbalances in metabolic networks are increasingly recognized as potential targets in various liver diseases, including NAFLD and NASH, offering novel avenues for therapeutic interventions. Utilizing liver-on-a-chip models to investigate metabolic dysregulation in the liver offer a unique platform to simulate liver metabolism and study its dysregulation, providing critical insights for targeted treatments and drug development. Objectives: (1) Develop 3D human (disease specific) models to mimic liver architecture and the NAFLD and NASH environment. (2) Develop liver-on-a-chip model-based readouts for hub molecules suitable for high-throughput screening; (3) Validate the model with tool compounds including nutraceuticals on 3D liver disease models.
Supervisor: Dorota Kurekwith https://www.mimetas.com/en/company/careers/ Link to DC14: HubMOL | UiT
Your tasks will include
- Development and implementation of novel organ- and disease models (specifically liver metabolism);
- Model validation (e.g. by performing compound challenges, immunoassays, using state-of-the art cell-based and molecular assays);
- Plan and execute experiments independently;
- Report on a regular basis to internal stakeholders;
- Disseminate your research in peer-reviewed journal
- Write standard operating procedures;
- Contribute to general lab duties.
About MIMETAS
MIMETAS is a rapidly growing company that specializes in human disease modelling using organ-on-a-chip technology. We are on a mission to pioneer the first generation of medicines grounded entirely in human data, using our unique disease modelling platform that is human, comprehensive, and scalable. Our disease models are designed to discover new therapeutic approaches and bring more drugs to patients by reducing attrition, while lowering development costs. MIMETAS has an open culture, where achievements go hand in hand with a fun place to work. Our close-knit team stays successful by maintaining a good atmosphere while working in a highly competitive field. MIMETAS’ headquarters are based in Leiden, The Netherlands and our manufacturing facility is based in Enschede, The Netherlands. We have subsidiaries in Gaithersburg, MD, USA, and Tokyo, Japan.
Gross salary:A competitive salary with benefits, such as a pension plan, all in line with EU guidelines EUR-Lex - C(2022)7550 - EN - EUR-Lex
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9)
- Proven prior knowledge in hub molecule relevant topics
- A high level of motivation and interest for topics of HubMOL
- High-level of collaborative and communicative skills
- Relevant expertise in cell metabolism and fields related to the HubMOL projects
- Excellent level of English speaking and writing skills (required).
Your profile
- You want to work in the lab in multi-disciplinary teams to tackle tough tissue modeling problems
- You have a master’s degree in biology, pharmaceutical sciences, biomedical sciences, bio-engineering, or a related field;
- You are experienced in high quality tissue culture, (confocal) microscopy and image analysis software;
- You have experience with (live) cell-based assays and molecular analysis techniques (incl qPCR, ELISA, IF);
- Your work is of high quality, you work accurately and safely;
- You are a motivated, flexible, and positive team player;
- You have excellent communication skills in English.
- You have a passion to support new therapy discovery and development, and have an affinity to work in an international, fast-growing high-tech environment at the edge of industry and academia
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences
Additional Information
We offer
- A challenging, full-time position;
- Challenging research projects on breakthrough science;
- Ample opportunities for personal development and growth;
- Dissemination of your research at the international stage;
- A competitive salary with benefits, such as a pension plan, all in line with EU guidelines,
- A fun team with colleagues from all over the world who love what they do;
- Friday afternoon drinks as part of an extensive program of social activities.
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions.
The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position.
Applications
Interested in this position? Please apply with your application letter (separate) and resume together with a scanned copy of all relevant diplomas or certificates that formally entitle you to embark on a doctorate, and two letters of recommendations or contact details of two referees (all in PDF) via 16 PhD Fellow positions in Hub Molecules of Metabolism and Signalling - Key regulators of Life (273496) | UiT The Arctic University of Norway
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- MIMETAS
- Country
- Netherlands
- Geofield
Contact
- Website
- d.kurek@mimetas.com