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Call for PhD Fellow position interested in applying for MSCA DN in Hub Molecules of Metabolism and Signalling -Key regulators of Life (HubMOL DC12)

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23 Jan 2025

Job Information

Organisation/Company
The University of Copenhagen
Department
Novo Nordisk Foundation Center for Basic Metabolic Research
Research Field
Biological sciences
Researcher Profile
First Stage Researcher (R1)
Positions
PhD Positions
Country
Denmark
Application Deadline
Type of Contract
Not Applicable
Job Status
Not Applicable
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules.  The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu

HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.

Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.

Subproject 12 with employment at the University of Copenhagen, Denmark  www.cbmr.ku.dk/research /:

The subprojects aims to understand the role of the NAD+ generating and consuming pathways for maintaining tissue function and adaptability in response to metabolic stress. We employ innovative preclinical models to manipulate NAD-related metabolites cell type-specifically and determine functional implications. We have developed several novel and unique experimental models and techniques related to in vivo animal research. 

We have preliminary data from quantitative mass spectrometric analysis of skeletal muscle that show key proteins in the insulin signaling cascade are ADP-ribosylated. Since ADP ribosylation (ADPr) is mediated by NAD+-consuming ADP-ribosyltransferases, this indicates a yet unrecognized interplay between insulin signaling and cellular NAD+ metabolism. Our hypothesis is that ADPr plays an essential role to regulate insulin sensitivity in skeletal muscle, and our over-arching aim is to determine the role of this posttranslational modification (PTM) for maintaining cellular glucose homeostasis and insulin action. Your tasks would be to define and compare insulin-induced ADP ribosylomes of insulin sensitive and resistant skeletal muscle, and to identify key modifications that are important for insulin signaling to mediate glucose disposal. We strive to understand the molecular basis for ADPr in skeletal muscle insulin resistance, and we are looking for candidates who are motivated to integrate data available from high-resolution mass spectrometry-based proteomics analyses with approaches in in vivo physiology and molecular biology.

Supervisor: Jonas Thue Treebak     https://cbmr.ku.dk/research/research-groups/treebakgroup/?pure=en/persons/5073 

Link to DC12: HubMOL | UiT

The Doctoral Candidate will be supervised by Associate Professor Jonas Thue Treebak. In the Treebak Group, we aim to define mechanisms linking cellular NAD+ to metabolic health. We want to understand the role of the NAD+ generating and consuming pathways for maintaining tissue function and adaptability in response to metabolic stress. We employ innovative preclinical models to manipulate NAD-related metabolites cell type-specifically and determine functional implications. We have developed several novel and unique experimental models and techniques related to in vivo animal research.  

About the Novo Nordisk Foundation Center for Basic Metabolic Research 

The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is an academic research Center that pioneers groundbreaking research towards better cardiometabolic health. Through collaborative interdisciplinary research from single-cell genomics to whole-body systems, CBMR aims to transform the basic understanding of cardiometabolic health and accelerate its translation into prevention and treatment strategies. The Center’s uniquely multi- and interdisciplinary approach combines research in genetics, physiology and pharmacology, to better understand the complex interplay of the many factors that drive cardiometabolic disease. You can learn more in the Executive Summary of CBMR's Strategy 2024–2028. CBMR was established in 2010 and has been in the Maersk Tower at PANUM since 2017. Around 260 employees create an international, highly collaborative research environment across disciplines.  

Place of employment 

The place of employment is at CBMR, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Gross monthly salary: DKK 42,786

Requirements

Research Field
Biological sciences
Education Level
Master Degree or equivalent
Skills/Qualifications
  • A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9) 
  • Proven prior knowledge in hub molecule relevant topics 
  • A high level of motivation and interest for topics of HubMOL
  • High-level of collaborative and communicative skills
  • Relevant expertise in cell metabolism and fields related to the HubMOL projects
  • Excellent level of English speaking and writing skills (required). 
Specific Requirements
  • A curious mindset with a strong interest in skeletal muscle metabolism, in vivo physiology, and bioinformatics. 
  • Basic knowledge about LC-MS/MS-based proteomics, sample preparation and MS data processing is an advantage.
  • Qualifications corresponding to a master’s degree related to the subject area of the project. Please note that your master’s degree must be equivalent to a Danish master’s degree (i.e., corresponding to 120 ECTS). 
  • Team player with strong interpersonal and communication skills. 

 

 

Languages
ENGLISH
Level
Excellent
Research Field
Biological sciences

Additional Information

Eligibility criteria

Mobility rule: 

Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.

Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.

Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions. 

 

Doctoral Candidates (DCs) rule: 

Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.

Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position. 

Selection process

Key criteria for the assessment of applicants 

  • Professional qualifications relevant to the PhD project 
  • Relevant work experience 
  • Publications 
  • The grade point average achieved 
  • Other professional activities 
  • Language skills 
  • The successful applicant is also required to be enterprising and to possess good   interpersonal skills 

The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions. 

The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position. 

Additional comments

Application procedure 

Your application, written in English, must be submitted electronically by clicking “16 PhD Fellow positions in Hub Molecules of Metabolism and Signalling - Key regulators of Life (273496) | UiT The Arctic University of Norway” and must include the following documents in PDF format: 
 

  • Motivated letter of application (max. one page)  
  • CV incl. education, experience, language skills and other skills relevant for the position 
  • Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted 
  • As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science 
  • Applicants with a master´s degree from abroad should also enclose a short description of the grading scale used 
  • Publication list (if relevant) 
  • Other information to consider: References and recommendations (if possible) 

Only applications submitted both during the general HubMOL call as well as through University of Copenhagen’s recruitment page will be considered. You can apply for the position through University of Copenhagen’s recruitment page here: PhD fellowship Marie Curie in Molecular Metabolism

 

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
The University of Copenhagen
Country
Denmark
Geofield

Contact

Website
E-Mail
jttreebak@sund.ku.dk
Mobile Phone
+45 2480 5398

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