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Call for PhD Fellow position interested in applying for MSCA DN in Hub Molecules of Metabolism and Signalling -Key regulators of Life (HubMOL DC11)

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23 Jan 2025

Job Information

Organisation/Company
The Research Center One Health Ruhr (RCOHR)
Research Field
Biological sciences
Researcher Profile
First Stage Researcher (R1)
Positions
PhD Positions
Country
Germany
Application Deadline
Type of Contract
Not Applicable
Job Status
Not Applicable
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules.  The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu 

HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.

Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.

Subproject 11 with employment at the Research Center One Health Ruhr (RCOHR) Essen Germany (https://www.uaruhr.de/researchallianceruhr/onehealthruhr.html.en)

The protein kinase mTOR is a central controller of metabolism and ageing. mTOR is dysregulated in most cancers as well as in metabolic, neurodegenerative and congenital disorders, and is therefore of major biomedical interest as a drug target and biomarker. mTOR is at the center of a complex signaling and metabolic network, and exists in two structurally and functionally distinct multiprotein complexes, mTOR complex 1 (mTORC1) and mTORC2. In response to growth factors, nutrients, energy and stress, mTORC1 enhances anabolic processes such as translation, and represses catabolic processes such as autophagy. In this project we have identified posttranslational modifications of mTORC1 regulatory proteins as well as several enzymes that are of interest in this context. However, the cellular impact of these modifications and the signaling and metabolic networks governing them are poorly understood. The HubMOL-funded DC will investigate how these enzymes and protein modifications link the mTOR kinase network to metabolism and identify the role of connected hub molecules. This goal will be achieved by combining biochemistry and cell biology techniques with state-of-the-art proteomics and metabolomics.

Supervisor: Kathrin Thedieck  https://metabolic-signaling.eu/prof-dr-kathrin-thedieck/  Lonk to DC11: HubMOL | UiT 

 

The DC will become a member of the newly founded Department for Metabolism, Senescence and Autophagy at the Research Center One Health Ruhr (RCOHR) in Essen, headed by Prof. Dr. Kathrin Thedieck. The RCOHR – from Molecules to Systems (https://www.uaruhr.de/researchallianceruhr/onehealthruhr.html.en) of the Universities of Duisburg-Essen, Dortmund and Bochum focuses on research into the fundamental mechanisms of health and disease, from the molecular level to higher-level systems. The ecosystem is the context, in which we consider the complex interactions between environmental health, animal health and human health in the sense of the “One Health” concept. The Department of Metabolism, Senescence and Autophagy is hereby particularly concerned with the influence of metabolic disruptors on oncogenic mechanisms and therapy response. The Faculty of Medicine of the University Duisburg-Essen enjoys an excellent reputation in the clinical and translational fields as well as in basic research. The key research areas oncology, cardiovascular disease, immunology and infectiology, translational neuro- and behavioral sciences and transplantation are internationally established. Duisburg-Essen is also site of the German Consortium for Translational Cancer research (DKTK, https://dktk.dkfz.de/standorte/essen-duesseldorf) and the National Center for Tumor Research (NCT, https://nct.dkfz.de/en/sites.html).  

The Department for Metabolism, Senescence and Autophagy is one of the top laboratories in the mTOR field with high-ranking publications and competitive funding. We offer regular retreats and participation in scientific conferences, a diverse, interdisciplinary and international team, a work environment characterized by mutual respect and an excellent scientific environment with attractive opportunities for collaboration with renowned partners worldwide. 

Gross salary: compensation will be according to TV-L EG 13

Requirements

Research Field
Biological sciences
Education Level
Master Degree or equivalent
Skills/Qualifications
  • A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9) 
  • Proven prior knowledge in hub molecule relevant topics 
  • A high level of motivation and interest for topics of HubMOL
  • High-level of collaborative and communicative skills
  • Relevant expertise in cell metabolism and fields related to the HubMOL projects
  • Excellent level of English speaking and writing skills (required). 
Specific Requirements
  • The candidate should have theoretical and practical knowledge in cell culture techniques, biochemistry techniques (e.g. immune detections, fractionations, enzyme assays) and microscopy. 
  • Previous experience in the field of mass spectrometry-based proteomics and/or metabolomics is a plus. 

We look for a self-motivated and team-oriented DC with strong communication skills, who has completed a MSc degree in Chemistry, Biology, Biochemistry, Pharmacy or a comparable discipline with a focus on biochemistry and/or cell biology. The candidate should optimally have theoretical and practical knowledge in cell culture techniques, biochemistry techniques (e.g. immune detections, fractionations, enzyme assays) and microscopy. Previous experience in the field of mass spectrometry-based proteomics and/or metabolomics is a plus.   

Languages
ENGLISH
Level
Excellent
Research Field
Biological sciences

Additional Information

Eligibility criteria

Mobility rule: 

Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.

Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.

Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions. 

 

Doctoral Candidates (DCs) rule: 

Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.

Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position. 

Selection process

The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions. 

The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position. 

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
The Research Center One Health Ruhr (RCOHR)
Country
Germany
Geofield

Contact

Website
E-Mail
kathrin.thedieck@uk-essen.de

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