- JOB
- Denmark
- EXPIRES SOON
Job Information
- Organisation/Company
- MS-OMICS APS
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Denmark
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 5 with employment at MS-Omics https://www.msomics.com/ in Denmark:
Modelling of microbial influence on NAD metabolisms combining LC-MS/MS methods for NAD and CoA metabolites, global metabolic profiling and metagenomic sequencing. The gut microbiome's potential influence on NAD and CoA metabolism involves the microbial breakdown of dietary compounds, which serve as NAD and CoA precursors, and the presence of bacterial enzymes that impact NAD and CoA biosynthesis and utilization. Additionally, gut-derived factors such as SCFAs, inflammation, and immune interactions may further modulate NAD and CoA metabolism by affecting nutrient absorption and cellular responses. The availability of mice intestinal samples from different sections of the gut allows a precise measurement of where and how metabolites are modified or absorbed.
Objectives: (1) Measure NAD metabolites, global metabolome and the metagenome in samples from mice (2) Elucidate gut-microbiome-NAD and CoA metabolism by identification of specific taxa and metabolic pathways responsible for NAD and CoA precursors synthesis and breakdown (3) Apply integrative multi-omics analysis for modelling the NAD metabolites, metabolic pathways in the gut microbiota.
Supervisor: Morten Danielsen md@msomics.com Link to DC5:HubMOL | UiT
Institution: Cmbio / MS-Omics
At Cmbio, we are innovators at the forefront of microbiome science and multi-omics research. Our team of over 100 experts spans microbiology, bioinformatics, metabolomics, molecular biology, and data science, bringing unparalleled expertise to advance the understanding and impact of the microbiome in global health. With labs in both the US and Denmark and a presence across the US, EU, and APAC regions, we are dedicated to creating breakthrough tools and analytical techniques that set new standards for the field. Together, we drive innovation to transform health and sustainability worldwide. MS-Omics – a Cmbio company and a leading metabolomics provider. MS-Omics combines first-class analytical and data processing services to provide a broad range of metabolomics platforms that support Life Science research. The daily work will be in our laboratories in Trørød, which is located just north of Copenhagen, Denmark.
Gross salary: 32.500 DKK/month + 5 weeks of vacation fully paid
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9)
- Proven prior knowledge in hub molecule relevant topics
- A high level of motivation and interest for topics of HubMOL
- High-level of collaborative and communicative skills
- Relevant expertise in cell metabolism and fields related to the HubMOL projects
- Excellent level of English speaking and writing skills (required).
- The candidate can be either a strong analytical scientist with a high interest in programming and modelling.
- Or the candidate could be a bioinformatician with LC-MS/MS and laboratory experience.
For this PhD grant we are looking for a skilled candidate with an master of science degree. The projects contains both laboratory work and programming/modelling work. The candidate can be either a strong analytical scientist with a high interest in programming and modelling. Or the candidate could be a bioinformatician with LC-MS/MS and laboratory experience.
On a personal level, you must be able to work independently and display a high-quality mindset. You will be working with scientists from other scientific disciplines working on a diversity of different projects so good communication skills are required for the position. We expect that you truly enjoy working with metabolomics and bioinformatics.
It is important that you are a team player and enjoy interacting with colleagues and customers. You have great problem-solving abilities, understand the advantages of mutual respect, have a positive mindset, and like to have a good laugh.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciencesChemistry » Analytical chemistryChemistry » Biochemistry
Additional Information
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions.
The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- MS-OMICS APS
- Country
- Denmark
- Geofield
Contact
- Website
- md@msomics.com