- JOB
- Norway
- EXPIRES SOON
Job Information
- Organisation/Company
- Simula Research Laboratory AS
- Department
- Department of Computational Physiology
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Norway
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 4 with employment at Simula https://www.simula.no, Norway, Department of Computational Physiology:
This subproject aims to study the role of hub molecules in cellular processes and explore their potential for treating metabolic diseases. Coenzyme A (CoA) is a hub molecule involved in many biochemical reactions and metabolism. Deficiency in CoA biosynthesis has been shown to increase the risk of life-threatening heart rhythm disorder. The goal of this project is to use computational modeling to understand the mechanisms underlying CoA disorder and arrhythmogenesis. To achieve this goal, the candidate will:
- Develop a detailed model of cardiomyocyte electrophysiology, including energetics and CoA synthesis.
- Investigate the link between CoA biosynthesis and its effect on the cardiac action potential.
- Conduct 3D simulations in patient-specific heart geometries to study how changes contribute to arrhythmia generation.
Supervisor: Hermenegild Arevalo (hermenegild@simula.no). Link to DC4: HubMOL | UiT
Simula: solving problems, making a difference.
Simula’s mission is to solve important and fundamental problems of science and engineering, with the main goal of benefiting and advancing society. We do this by concentrating on five select research areas in ICT and performing excellent research, by developing our people, and by spinning out applicable results into profitable startups
About Simula and Norway
Simula Research Laboratory AS is a publicly owned research lab located in Oslo, Norway. Simula conducts Information and Communication Technology (ICT) research in the fields of scientific computing, software engineering, communication systems, machine learning and cybersecurity.
Simula's main objective is to create knowledge about fundamental scientific challenges that are of genuine value for society. This is achieved through high-quality research, education of graduate students, industry collaboration, technology transfer, and commercialization. Since 2001, scientific evaluations conducted by the Research Council of Norway has repeatedly placed Simula at the forefront of international research in ICT. The most recent in-depth evaluation was published in 2017, grading the full range of research at Simula as “excellent”.
Simula appreciates diversity. We currently employ approximately 155 individuals from 35 countries and strive to create a family-friendly working environment. We are an equal opportunity employer and encourages women to apply.
Simula has a close collaboration with leading universities in Norway and abroad, both in terms of research and education, and facilitates extended research stays abroad. Our Master's and PhD students conduct their research at Simula, and attend courses and receive their degrees from university partners.
Gross salary: 558.800 NOK/year
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9)
- Proven prior knowledge in hub molecule relevant topics
- A high level of motivation and interest for topics of HubMOL
- High-level of collaborative and communicative skills
- Relevant expertise in cell metabolism and fields related to the HubMOL projects
- Excellent level of English speaking and writing skills (required)
- We are looking for interested candidates who have a background in computational modeling and biological systems.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences
Additional Information
Simula Offers
- Excellent opportunities for performing high quality research, as part of a highly competent and motivated team of international researchers and engineers;
- An informal and inclusive international working environment;
- Generous support for travel and opportunities to build international networks, through established collaboration with industry, exchange programs and research visits with other universities, and funding to attend conferences.
- Modern office facilities located at the center of Oslo.
- A competitive salary.
- Numerous benefits: access to company cabin, sponsored social events, generous equipment budgets (e.g., computer, phone and subscription), subsidized canteen meals, comprehensive travel/health insurance policy, etc.
- Relocation assistance: accommodation, visas, complimentary Norwegian language courses, etc
- Wellness and work-life balance. Our employees' health and well-being is a priority and we encourage them to make use of our flexible work arrangements to help balance their work and home lives efficiently.
Simula Research Laboratory uses background check in our recruitment process.
According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
Employment for this position will be made according to the act relating to Control of the export of strategic goods, Services and Technology. Candidates who by assessment of the application and any attachments are considered to be in conflict with the export control regulations will not qualify for this position.
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions.
The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Simula Research Laboratory AS
- Country
- Norway
- Geofield
Contact
- City
- Oslo
- Website
- hermenegild@simula.no