- JOB
- Netherlands
- EXPIRES SOON
Job Information
- Organisation/Company
- University Medical Center Groningen
- Department
- Department of Biomedical Sciences
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Netherlands
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 3 with employment at the University Medical Center in Groningen https://bscs.umcg.nl/en/, Netherlands:
This subproject will focus on coenzyme A biosynthetic pathways in cell and animal models and explore supplementation strategies in genetic deficiencies and their effect on other hub molecules with a focus on NAD. While most inborn errors in CoA biosynthesis lead to neurodegenerative diseases, some mutations lead to dilated cardiomyopathies. The organ specific effects of CoA deficiencies are little understood and will be investigated in the project.
Supervisor: Ody Sibon, https://bscs.umcg.nl/en/people/sibon-ody-c-m/ Link to DC3: HubMOL | UiT
Subproject 15 with employment at the University Medical Center in Groningen Netherlands https://bscs.umcg.nl/en/, Netherlands
This subproject will focus on the role of coenzyme A in energy metabolism, particularly in inherited disorders of fatty-acid oxidation and CoA biosynthesis. The relationship between the primary enzyme deficiencies and the disease symptoms is often incompletely understood. The complexity of the metabolic pathways and their high connectivity require a systems biology approach. In this project we will explore the effect of the nutritional status on CoA and fatty-acid dynamics using stable-isotope labelling, mass spectrometry and computational modelling.
Supervisor: Barbara Bakker https://www.rug.nl/staff/b.m.bakker/ Link to DC15: HubMOL | UiT
Description UMCG:
The University Medical Center Groningen (UMCG) is one of the largest hospitals in the Netherlands and the largest employer in the north of the Netherlands. Over 10,000 employees are working on patient care and on cutting-edge scientific research, focused on ‘healthy and active ageing’. The UMCG hosts multiple centres of expertise for rare disorders. Research at the UMCG combines fundamental and patient-orientated (clinical) research, thus stimulating the development of new clinical and research opportunities at the national and international level. The UMCG is located in the center of the vibrant city of Groningen.
For the Sibon laboratory position we are looking for a candidate with a master in biochemistry, cell biology or life sciences and with Interest fundamental research and in (coenzyme A) metabolism in health and disease, and clinical translation.
For the Bakker laboratory positionwe are looking for a candidate with a master in e.g. biochemistry, analytical chemistry, or chemical engineering, with an interest at the interface of fundamental biomedical science, computational modelling, and clinical translation.
The positions will be for 3 years with the possibility of an extension for a 4th year.
The salary will be a maximum of € 3.824,00 gross per month, based on a full-time appointment.
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9)
- Proven prior knowledge in hub molecule relevant topics
- A high level of motivation and interest for topics of HubMOL
- High-level of collaborative and communicative skills
- Relevant expertise in cell metabolism and fields related to the HubMOL projects
- Excellent level of English speaking and writing skills (required)
Subproject 3
- Interest in fundamental research and in (coenzyme A) metabolism in health and disease,
- Clinical translation.
Subproject 15
- Interest at the interface of fundamental biomedical science, computational modelling, and clinical translation.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciencesChemistry » Analytical chemistry
Additional Information
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions.
The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position.
- Website for additional job details
Work Location(s)
- Number of offers available
- 2
- Company/Institute
- The University Medical Center in Groningen
- Country
- Netherlands
- Geofield
Contact
- Website
- o.c.m.sibon@umcg.nlb.m.bakker01@umcg.nl