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  • JOB
  • Norway
  • EXPIRES SOON

Call for PhD Fellow position interested in applying for MSCA DN in Hub Molecules of Metabolism and Signalling -Key regulators of Life (HubMOL DC2,9)

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23 Jan 2025

Job Information

Organisation/Company
UiT The Arctic University of Norway
Department
Department of Arctic and Marine Biology
Research Field
Biological sciences
Researcher Profile
First Stage Researcher (R1)
Positions
PhD Positions
Country
Norway
Application Deadline
Type of Contract
Not Applicable
Job Status
Not Applicable
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules.  The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu 

HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.

Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.

Subproject 2 with employment at The Arctic University of Norway in Tromsø, Norway  https://uit.no/enhet/amb 

Establish mathematical models resembling subcellular NAD, FAD, SAM, ATP and CoA dynamics and their linkage. This subproject will include:

  • The collection of biochemical knowledge and kinetic parameters of enzymes and transporters involved in the metabolism of these hub molecules using AI assisted literature search
  • The compilation of a searchable database with the collected information
  • Analysis of stable isotope labelling data and development of a mathematical model integrating newly derived data and literature based prior knowledge

Supervisor: Ines Heiland https://uit.no/research/bsysbio Link to DC2 :HubMOL | UiT 

Subproject 9 with employment at The Arctic University of Norway in Tromsø, Norway https://uit.no/enhet/amb 

Develop mathematical models linking the dynamics of S-Adenosyl Methionine (SAM)  and Acetyl-CoA metabolism to protein acetylation and methylation. This subproject will include:

  • Develop data analysis and modelling-based approaches to correct stable isotope-based protein modification dynamics for cofactor biosynthesis dynamics
  • Build and extend both small scale dynamic and genome scale metabolic models

    to reflect substrate requirements through protein modifications and consequently potential limitations for PTMs.

    Supervisor: Ines Heiland https://uit.no/research/bsysbio  Link to DC9: HubMOL | UiT

      Gross salary: 536 200 NOK/year with a 3% yearly increase for both positions

Requirements

Research Field
Biological sciences
Education Level
Master Degree or equivalent
Skills/Qualifications
  • A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9) 
  • Proven prior knowledge in hub molecule relevant topics 
  • A high level of motivation and interest for topics of HubMOL
  • High-level of collaborative and communicative skills
  • Relevant expertise in cell metabolism and fields related to the HubMOL projects
  • Excellent level of English speaking and writing skills (required)
Specific Requirements

DC2: 

  • Documented experience with LC-MS analytics or profound knowledge of cellular metabolism
  • Programming skills, preferentially in Python are advantageous 

DC9:

  • Documented experience with LC-MS analytics or profound knowledge of cellular metabolism
  • Programming skills, preferentially in Python are advantageous but are not required, but it is expected that the candidates develops the required programming skills within the course of the project as a large part of the project is programming based
Languages
ENGLISH
Level
Excellent
Research Field
Biological sciencesChemistry » Analytical chemistryChemistry » Biochemistry

Additional Information

Eligibility criteria

Application

  • Cover letter explaining your motivation and which position in HubMOL you are applying for
  • CV
  • Diploma for bachelor's and master's degree
  • Transcript of grades/academic record for all degrees
  • Explanation of the grading system for foreign education (Diploma Supplement if available)
  • Documentation of English proficiency
  • References with contact information
  • Master’s thesis, and any other academic works

Qualification with a master’s degree is required before commencement in the position. If you are near completion of your master’s degree, you may still apply and submit a draft version of the thesis and a statement from your supervisor or institution indicating when the degree will be obtained. You must still submit your transcript of grades for the master’s degree with your application.

All documentation to be considered must be in English. Diplomas and transcripts must also be submitted in the original language, if not in English. If English proficiency is not documented in the application, it must be documented before starting in the position. We only accept applications and documentation sent via Jobbnorge within the application deadline. 

Mobility rule: 

Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.

Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.

Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions. 

Doctoral Candidates (DCs) rule: 

Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.

Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position. 

Selection process

The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions. 

The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position. 

Website for additional job details

Work Location(s)

Number of offers available
2
Company/Institute
The Arctic University of Norway
Country
Norway
Geofield

Contact

City
Tromsø
Website
Street
Hansine Hansnes vei
Postal Code
9037
E-Mail
hubmol@bfe.uit.no

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