- JOB
- Norway
STATUS: EXPIRED
21 Jan 2025
Job Information
- Organisation/Company
- University of Bergen
- Department
- The Department of Biomedicine
- Research Field
- Biological sciences
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Norway
- Application Deadline
- Type of Contract
- Not Applicable
- Job Status
- Not Applicable
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
In the context of the European Horizon funded Marie Skłodowska-Curie Actions - doctoral network HubMOL - Hub Molecules of Metabolism and Signalling – Key regulators of Life we have 16 PhD positions available at 10 different research institutions and 4 companies across Europe. HubMOL brings together internationally leading academic and industrial expertise in epigenetics, mathematical modelling and high-resolution stable isotope labelling based analysis of the dynamics of metabolic cofactors and post translational modifications (PTMs) and will use advanced in vitro and animal models for translational studies to develop knowledge based nutritional intervention strategies for hub molecules. The hub molecules of life that include ATP (adenosine triphosphate), NAD (nicotinamide adenine dinucleotide), CoA (coenzyme A), FAD (flavine adenine dinucleotide) and SAM (S-adenosylmethionine), comprise a set of cofactors that are crucial for all cellular functions. More information can be found at the project website: www.hubmol.eu
HubMOL has 16 subprojects and applicants have to specify the subproject they apply to and can mention additional 2 subprojects of interest. Motivation for the selection should be provided. Applicants that do not specify the subproject or provide the motivation for their choice will not be considered.
Please make sure to clearly indicate the position (e.g., DC1, DC2, etc.) you are applying for in the subject line of your application or in the relevant section of the application form.
Subproject 1 with employment at the Department of Biomedicine, University of Bergen. Norway https://www.uib.no/en/biomedisin:
Dynamics and interdependence of cellular NAD, CoA, SAM, FAD and ATP pools
Metabolic conversions and signaling functions of different hub molecules are interconnected. Previous work has also demonstrated that the level of one hub molecule can be limited by the deficiency of another one owing to its cofactor role. However, while these interdependencies are critical for cell homeostasis, they have not been systematically studied. Objectives: (1) Establish analytical procedures to determine concentrations and turnover rates of NAD, CoA, FAD, SAM and ATP and their biosynthetic intermediates (2) Set up suitable cell model systems with modulated HubMOL concentrations and turnovers (3) Establish interdependencies of hub molecule dynamics and exploit them to re-adjust imbalances.
Supervisor: Mathias Ziegler (group webpage: https://www.uib.no/en/rg/nad-group) Link to DC1: HubMOL | UiT
Gross salary: 536 200 NOK/year with a 3% yearly increase
Where to apply
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- A master in biochemistry, cell biology, biomedicine, analytical chemistry (subprojects 1,2,5,8, 9,15) or bioinformatics with good understanding of biochemistry (subprojects 2,5,9)
- Proven prior knowledge in hub molecule relevant topics
- A high level of motivation and interest for topics of HubMOL
- High-level of collaborative and communicative skills
- Relevant expertise in cell metabolism and fields related to the HubMOL projects
- Excellent level of English speaking and writing skills (required)
Specific Requirements
- Profound knowledge of cellular metabolism
- Documented practical experience with cell biology or LC-MS analytics
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciencesChemistry » Analytical chemistry
Additional Information
Eligibility criteria
Mobility rule:
Researchers can be of any nationality, but they are required to undertake physical, transnational mobility (i.e., move from one country to another) when taking up their appointment.
Additionally, researchers shall not have resided or carried out their main activity in the country of their host organization for more than 12 months in the 3 years immediately prior to the reference date.
Researchers who are refugees in an EU Member State or a Horizon Europe Associated Country according to the Geneva Convention are exempted from the mobility rules above if they fulfil the other eligibility conditions.
Doctoral Candidates (DCs) rule:
Applicants must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible. See Article 6.2.A (b) (i) of the HE unit model grant agreement.
Applicants must meet the admission requirements of the doctorate degree program of the hiring institutions for each position.
Selection process
The applicants will be assessed by the expert committee. The committee`s mandate is to undertake an assessment of the applicants ´qualifications based on the written material presented by the applicants, and the detailed description draw up for the positions. The applicants who are assessed as best qualified will be called to an interview. There will be a two-stage interview process. The interview should among other things, aim to clarify the applicant´s motivation and personal suitability for the position.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- University of Bergen
- Country
- Norway
- Geofield
Contact
- City
- Bergen
- Website
- mathias.ziegler@uib.no