You will contribute to our pioneering efforts to dissect the structural dynamics of GPCRs using state-of-the-art tools and techniques.

We are seeking a highly motivated Postdoctoral Researcher for up to three years to join the "Integrative Biophysics of Membranes" team at the Centre de Biologie Structurale (CBS) in Montpellier, France.
Your key responsibilities will include:
• Developing novel conformational FRET sensors via bioorthogonal labeling strategies using genetic code expansion in mammalian cells.
• Employing cutting-edge confocal 2- and 3-color single-molecule FRET to characterize GPCR conformational states and dynamics with exceptional spatial and temporal resolution.
• Performing molecular biology, membrane protein purification, mammalian cell culture, bioorthogonal fluorescence labeling, and advanced single-molecule FRET data analysis.
• Establishing and optimizing experimental protocols to drive the project forward.

G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors in humans, orchestrating countless cellular responses by sensing diverse external stimuli. While static high-resolution structures of GPCRs have revolutionized our understanding of their function and driven drug discovery, they only reveal part of the story. GPCRs are dynamic entities, constantly transitioning between multiple conformational states under native conditions. To unlock the full potential of GPCR-targeted drug development, it is essential to unravel their structural dynamics and provide a complete mechanistic picture of their function.

If you are passionate about exploring the "4th dimension" of structural biology—protein dynamics—and eager to contribute to cutting-edge research on a pharmacologically crucial target, we invite you to join our team.

What We Offer
The Centre de Biologie Structurale (CBS) in Montpellier is a world-class research center combining the expertise of CNRS, INSERM, and the University of Montpellier. Located in the vibrant south of France, CBS specializes in structural biology, biophysics, and bioengineering, driving discoveries in both fundamental science and healthcare applications.

As part of our team, you'll work in a highly collaborative and multidisciplinary environment, leveraging complementary expertise in cell biology, protein engineering, AFM, super-resolution microscopy, and NMR. This project includes close collaboration with the teams of P. Rondard and J.P. Pin, renowned leaders in GPCR pharmacology and structural research.

By joining us, you will gain access to cutting-edge facilities and mentorship to advance your scientific career while contributing to groundbreaking research.