Position in the project: Master’s student or equivalent level (with a Bachelor’s degree)

Scientific discipline: molecular biology, biochemistry, ageing biology
Job type: stipend
Number of job offers: 1
Remuneration amount/month: stipend of up to 1.500 PLN/month
Position starts: As soon as possible
Period of contract: 6 months

Institution: IMol Polish Academy of Science
Project leader: Dr. Hanna Salmonowicz
Project title: "Dynamics of the OXPHOS system in cellular senescence”. Project is carried out within the “Sonatina” programme of the National Science Centre.

Project description:
Mitochondrial OXPHOS system is a set of five large multiprotein complexes that constitute the “heart” of mitochondria. They drive energy production and metabolism. Interestingly, OXPHOS complexes are not necessarily degraded as a whole but individual elements can be exchanged when damaged. We know OXPHOS can change in response to stress. Yet, what happens to the OXPHOS system, particularly how it becomes repaired, remains enigmatic during a cell stress response known as cellular senescence. We aim to better understand how the OXPHOS system is maintained when cell enter senescence, cellular state associated with increased inflammation and resistance to cell death. We use biochemical and proteomic tools to track OXPHOS turnover patterns and identify mitochondrial protein quality control mechanisms
that take care of the OXPHOS machines in senescent cells. We are also interested to establish how OXPHOS quality control impacts on the cell phenotypes that contribute to senescence cells’ pathological role in ageing. Accomplishing the goals of the project will contribute to our knowledge on how cells respond to stress as well as directs us towards novel anti-ageing (anti-senescence) strategies.

More details: https://projekty.ncn.gov.pl/index.php?projekt_id=546275 

Key responsibilities of candidates:
1. Participate in experimental design;
2. Conduct research experiments (independently and in collaboration with the supervisor) using culture of human cells; basic biochemical methods such as Western blotting, analysis of native complex status with Blue Native PAGE Western blotting, preparation of samples for proteomic analysis; genetic engineering with CRISPR/Cas9 system;
3. Participate in data analysis and dissemination of results among the scientific and broader community.
 

Requirements of candidates:
Bachelor's degree in Biology/Biochemistry/Biotechnology or a related field;

Required documents:
1. Letter of motivation
2. CV
3. If possible, a letter of reference from a senior lab member or supervisor whom you worked with during your Bachelor’s project or internship or from a teacher from the undergraduate course (reference letter is optional, not required)

We offer:
1. Participation in a cutting-edge scientific research project addressing key questions of basic biology with a focus on biomedical application;
2. Training in the scientific method, especially biochemical and genetic laboratory techniques;
3. Possibility of co-authorship of scientific articles;
4. Work in a brand-new research facility within a stimulating, international environment;

How to apply:
The required documents must be sent by e-mail in PDF format to h.salmonowicz@imol.institute before the deadline.
To allow us to process your data, please include the following statement in your application:
“I hereby consent to have my personal data processed by The International Institute of Molecular
Mechanisms and Machines Polish Academy of Sciences, with its registered office Flisa 6, 02-247
Warszawa for the purpose of carrying out a recruitment process and I agree to a transfer of provided data to
any entity responsible for the implementation of ReMedy project. I have been informed of my rights and
duties. I understand that the provision of my personal data is voluntary.”

Application deadline:
15.11.2024 - 23:59 (CET)