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4 Jul 2024

Job Information

Organisation/Company
Malopolska Centre of Biotechnology
Department
Administration
Research Field
Biological sciences » Other
Researcher Profile
Recognised Researcher (R2)
Positions
PHD Positions
Country
Poland
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

RECTOR of the Jagiellonian University announces a selection procedure for the position of an  ASSISTANT PROFESSOR

Project title: OPUS17 (NCN): „Metabolites of Baltic cyanobacteria as natural compound library for high throughput screening and the development of new antiviral drugs”.  PSP: K/PBO/000755.

 

Field of science: Natural sciences

Discipline: Biological Science

Scope: Virology

 

Project description:

Despite significant progress in medicine, infectious diseases still constitute a major threat to public health and belong to the leading causes of death. Currently, the list of antiviral drugs is limited to only 90 substances, and still there is no cure for more than 200 viral infections. While recurring epidemics of such infectious as measles 3  or chickenpox may pose a threat to public health, the real danger lies in new pathogens that cross borders or/and are transmitted from animals and rapidly spread in the human population. Within this project, the development of new antiviral agents active against coronavirus and flaviviruses is initiated. These viruses pose a major threat, due to the unpredictability of their prevalence and infectious properties. A development of new antivirals is essential to control the existing threats, but also to protect the population in the case of emergence of yet unknown viral variants. In the work, cyanobacterial metabolites as ultra-rich libraries of biologically active compounds will be explored. In preliminary tests, we revealed that extracts from Baltic cyanobacteria constitute a promising source of compounds active against flaviviruses and coronaviruses. The positive results encouraged us to plan more detailed studies with the aim to discover new cyanobacterial antiviral agents (CAAs) and identify their mechanisms of action. To achieve the goals of the project, the following tasks will be implemented: (1) isolation and identification of new antiviral compounds from cultures of Baltic cyanobacteria; (2) construction of CAAs library; (3) determination of CAAs mechanisms of action and (4) assessment of the effects on other targets. We think that planning a synthesis of CAA within this project, without any knowledge about the structure of the compound, would not be feasible. Consequently, the work will have to be based only on natural sources of the CAAs – which is a limiting factor. However, the library of CAAs (compounds and the repository), the results of all performed bioassays and analyses, as well as the data from genome mining – as an outcome of the project – will pave the way for successful drug development in further studies. They should include QSAR (quantitative structure-activity relationship) and optimization of CAA pharmacological properties, development of the most effective method of CCA synthesis, ADME (adsorption, distribution, metabolism, excretion), toxicological tests on animal models and other experiments usually preceding clinical test. 

 

Planned duration of employment: 6 months

Expected date of employment commencement: August/September 2024  

 

Scope of duties:

according to the Work Regulations of the Jagiellonian University Annex 1 to the Work Regulations of the Jagiellonian University – Model scopes of responsibilities and duties of academic teachers.

The candidates duties will be as follows:  

Assistant professor will conduct research under the project „Metabolites of Baltic cyanobacteria as natural compound library for high throughput screening and the development of new antiviral drugs”. The research will be performed at the Jagiellonian University's Malopolska Centre of Biotechnology. The assistant professor will work with the team involved in the project.  

This will include laboratory work, experimental setup, and sample processing. The candidate can count on access to extensive laboratory and equipment resources.

Where to apply

E-mail
job.mcb@uj.edu.pl

Requirements

Research Field
Biological sciences » Other
Education Level
PhD or equivalent
Skills/Qualifications

Requirements:

The selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to § 165 of the Statute of the Jagiellonian University:  

• holding at least a doctoral degree;

• having relevant scientific achievements;

• taking active part in scientific life.

Specific Requirements

Additional requirements and expectations:

An ideal candidate will:  

• have a master degree in molecular biology or in related fields

• be experienced in working with biosafety class 2 infectious material;

• be proficient in English language of at least C1 level to handle scientific literature;  

• have documented scientific publications in molecular virology (no less than 2 papers with first authorship in impact factor journals);

• experience in cell culture,

• experience in molecular virology

• have experience in molecular biology.

The candidate should meet the requirements arising from the Regulations on awarding funds for the implementation of tasks financed by the National Science Center in the field of research projects, available at: https://www.ncn.gov.pl/sites/default/files/pliki/uchwalyrady/2019/uchwa…

• obtained a doctoral degree no earlier than 7 years before the year of employment in the project (This period may be extended by the time spent on long-term (over 90 days) documented sickness benefits or rehabilitation benefits due to incapacity for work. Additionally, the number of months of leave related to the care and upbringing of children granted to under the terms set out in the Labor Code, and in the case of women - 18 months for each born or adopted child, if this method of indicating breaks in a scientific career is more favorable).

• will not be a person for whom the project manager was a supervisor or auxiliary supervisor in his/her doctoral thesis;

• in the last two years before taking up employment in the project, she was not employed under an employment contract in the entity where the research project will be implemented;

• during the period of receiving this remuneration, he will not receive any other remuneration from funds allocated as direct costs from research projects financed in NCN calls;

• during the period of receiving this remuneration, the employee will not be employed by another employer under an employment contract, including an employer based outside Poland. 

Research Field
Biological sciences » Other

Additional Information

Benefits

We offer:

• stable employment based on an employment contract at the renowned university,

• cooperation with the interdisciplinary academic community represented by well-known scientists,

• scientific support as well as the possibility of qualifications improvement and professional development,

• access to research infrastructure,

• benefits in the form of a Multisport card, sports activities, medical packages, group insurance,

• additional social benefits. 

Selection process

Required application documents:

1. CV,

2. personal questionnaire filled in by the candidate,

3. scan of the doctoral diploma or a diploma confirming the candidate’s habilitation degree, if applicable,

4. information on the candidate’s scientific, teaching and organisational achievements,

5. declaration of the candidate, confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,

6. statement under Article 113 of the Law on higher education and science,

7. statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialisation in force at the Jagiellonian University.



Declaration forms (no. 5-7) and personal questionnaire template (no. 2) can be obtained at:



https://cso.uj.edu.pl/en_GB/dokumkandyd

Additional application documents:

1. full Curriculum vitae

2. list of publications (including publisher and number of citations),

3. review of the doctoral thesis or dissertation - if the Candidate has one,

4. opinion on the Candidate's predisposition and qualifications for scientific work,

5. statement of compliance with the competition requirements, with a detailed description of how each requirement was met. 

The course of selection procedure:

The first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate. The Candidate has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment.



The selection procedure is conducted in accordance with The Policy of Open, Transparent and Merit-Based Recruitment Process.

Additional comments

Form of submission:

by e-mail to the address: job.mcb@uj.edu.pl,  

title: Assistant Professor_OPUS 17_post-doc_KP - Name and Last Name



Expected date of the selection procedure settlement: 05.08.2024 at the latest 

Method of communicating of the results of the selection procedure: by e-mail  



Questions: For further information please contact by e-mail: job.mcb@uj.edu.pl 

In the selection procedure, the Jagiellonian University follows the principles of the European Charter for Researchers and a Code of Conduct for the Recruitment of Researchers.

Jagiellonian University does not provide housing.  

Work Location(s)

Number of offers available
1
Company/Institute
Malopolska Centre of Biotechnologu, Jagiellonian University
Country
Poland
Geofield

Contact

State/Province
Malopolska
City
Cracow
Website
Street
Gronostajowa 7a
Postal Code
30-387
E-Mail
job.mcb@uj.edu.pl

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