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Call for 9 PhD fellowships within the MSCA DN project GLYCO-N: GLYCOprotein N-glycosylation from non-life to eukaryotes a Doctoral Network to expand the knowledge on a ubiquitous posttranslational modification of proteins.

4 Mar 2024

Job Information

Organisation/Company
Università degli Studi di Napoli Federico II
Department
Chemical Sciences
Research Field
Chemistry » Organic chemistry
Chemistry » Biochemistry
Pharmacological sciences » Pharmacy
Biological sciences » Biology
Researcher Profile
First Stage Researcher (R1)
Country
Italy
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
36-40
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
HE / MSCA
Marie Curie Grant Agreement Number
101119499
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

  • Introduction:

The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop different innovative strategies to 1) understand the diversity and structural complexity of archaeal, microalgal and viral N-glycosylation and 2) harness this knowledge for new solutions in biomedicine and biotechnology.

Protein N-glycosylation, or the attachment of oligo- and polysaccharides at specific asparagine residues, is conserved throughout life, and is now observed even in the viral world. In contrast to most of eukaryotes, whose well-studied N-glycosylation machineries are relatively simple, archaea, microalgae, viruses and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse N-glycans. Because protein N-glycosylation occurs far downstream of protein synthesis the complexity and diversity in N-glycan structures are poorly understood. GLYCO-N program has the bold task to dissect the N-glycosylation pattern harbored by archaea, microalgae and viruses, because aware that any discovery hold promise to shed light in different areas, ranging from drug discovery (antimicrobials) to biotechnology (biologics, glycoprotein and glycoprocessing enzyme engineering for materials and life sciences).

The GLYCO-N network brings together a diverse group of glycobiology researchers with world-leading expertise in carbohydrate chemistry, microbiology, (bio)organic chemistry, computational and structural (glyco-)biology, bioinformatics and chemical biology. The GLYCO-N DCs will have their own individual project with one GLYCO-N expert and will, through research internships, be exposed to complementary Glycoscience.

The selected PhD candidates will experience an international and interdisciplinary training and participate in a series of scientific, technical and complementary skills training events, and secondments to other participating institutions. The position will allow the students to participate in an exciting multidisciplinary research and training programme, enhancing their career perspectives. 

 

  • The Glyco-N Consortium

Beneficiaries

The following institutions will directly recruit the DCs:

 

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II (UNINA), NAPOLI, Italy, Department of Chemical Sciences, Prof. Antonio Molinaro (Coordinator of the GYCO-N project)

 

UNIVERSITEIT LEIDEN (UL), LEIDEN, Netherlands, Leiden Institute of Chemistry, Prof. Hermen Overkleeft

 

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS (CIC bioGUNE), DERIO BIZCAYA, Spain, Prof. Prof. Jesús Jiménez-Barbero

 

UNIVERSITAT DE BARCELONA (UB), BARCELONA, Spain, Department of Chemistry, Prof. Carme Rovira

 

DANMARKS TEKNISKE UNIVERSITET (DTU), KONGENS LYNGBY, Denmark, Department of Biotechnology and Biomedicine, Prof. Bernard Henrissat

 

UNIVERSITE DE ROUEN NORMANDIE (URN), MONT SAINT AIGNAN, France, Laboratory GlycoMEV, Prof. Muriel Bardor

 

UNIVERSITAET DUISBURG-ESSEN (UDE), ESSEN, Germany, Faculty of Chemistry, Prof Bettina Siebers and Prof. Markus Kaiser

 

Associated Partners with national fundings

The following institution will directly recruit the DCs:

IMPERIAL COLLEGE LONDON (UL), LONDON, UK, Chemistry, Dr. Benjamin Schuman

 

Associated Partners

The following Institutions and companies are part of the consortium and will contribute to training

activities, including secondments:

Atlas Molecular Pharma S.L. (AMP), Spain, Dr. Oscar Millet

Zelula Biopharma SL (ZB), Spain, Dr. Asís Palazón

Alga Biologics (AB), France, Dr. Catherine Gallot

Samabriva (SAM), France, Dr. Marina Guillet

Isuschem Srl (IC), Italy, Prof. Vincenzo Benessere

Universidad del Pais Vasco (UPV/EHU), Spain, Prof. Dr. Jesús Jiménez-Barbero

Innovation Acta Srl (INN-ACTA), Italy, Dr. Paola Cesaroni

 

  • Research Projects: Applications must be sent by email to the contact specified under the list of each research project

Position

Project title

Host Institution

Reference tutor(s) for PhD application and email

DC1

N-glycosylation in the extremophile archaeae

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II, Italy

Prof. Antonio Molinaro; Prof. Cristina De Castro molinaro@unina.it; decastro@unina.it

DC2

Study of the glycosylation machinery of archaea: a new perspective to unravel the evolutionary history of the tree of life

DANMARKS TEKNISKE UNIVERSITET, Denmark

Prof. Bernard Henrissat;

bernard.henrissat@gmail.com

 

DC3

Study of the function of glycosyltransferases in the crenarchaeal model organism Sulfolobus acidocaldarius to unravel their potential for biotechnological application

UNIVERSITAET DUISBURG-ESSEN, Germany

Prof Bettina Siebers; Bettina.siebers@uni-due.de

 

DC4

Structure and molecular recognition of viral N-glycoproteins

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS, Spain

Prof. Jesús Jiménez-Barbero; jjbarbero@cicbiogune.es

 

DC5

Designer molecules to interfere with host and viral N-glycosylation processing

UNIVERSITEIT LEIDEN, Netherland

Selection closed

 

DC6

Unraveling the xylosylation pathway of N-glycoproteins in microalgae

UNIVERSITE DE ROUEN NORMANDIE (France)

Prof. Muriel Bardor; muriel.bardor@univ-rouen.fr

Dr Elodie Rivet;

elodie.rivet@univ-rouen.fr

 

DC7

Modeling of mechanisms in wild type and engineered archaeal and microalgal glycoprocessing enzymes for the efficient synthesis of (neo)-glycans

UNIVERSITAT DE BARCELONA, Spain

Prof. Carme Rovira; recruitment.roviralab@gmail.com

DC8

Inhibitors and activity-based probes targeting host and viral glycosyltransferases

UNIVERSITEIT LEIDEN, Netherland

Selection closed

DC9

Mining chlorovirus PBCV-1 genome to decipher the N-glycosylation biosynthetic pathway

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II, Italy

Prof. Cristina De Castro; Prof. Antonio Molinaro; decastro@unina.it; molinaro@unina.it

 

DC10

Development of chemical probes for studying N-glycosylation from bioactive metabolites

UNIVERSITAET DUISBURG-ESSEN, Germany

Prof. Markus Kaiser; markus.kaiser@uni-due.de

 

DC11

Unraveling how viral glycosylation machineries affect host glycoproteins

Imperial College London, UK

Dr. Benjamin Schumann; ben.schumann@crick.ac.uk

To apply, please also check the job position at:

https://www.imperial.ac.uk/jobs/search-jobs/description/index.php?jobId=18419&jobTitle=Research+Assistant+in+Chemical+Glycobiology

Additional details on the individual research projects can be found at www.glyco-n.eu or directly asked by email to the reference tutors for the PhD application.

Requirements

Research Field
Chemistry » Organic chemistry
Education Level
Master Degree or equivalent
Research Field
Chemistry » Biochemistry
Education Level
Master Degree or equivalent
Research Field
Pharmacological sciences » Pharmacy
Education Level
Master Degree or equivalent
Research Field
Biological sciences » Biology
Education Level
Master Degree or equivalent
Skills/Qualifications
  • Applicants must have good knowledge and interest in Carbohydrate chemistry, microbiology, (bio)organic chemistry, computational and structural biology, bioinformatics and chemical biology
  • Research experience on these topics is considered an advantage but not mandatory
  • Applicants must speak and write fluently in English
Specific Requirements

Research Field: Chemistry, Organic chemistry, Carbohydrate chemistry, Biochemistry, Structural Biology, Molecular Biology, Pharmacy, Biotechnology

Education Level: Master Degree or equivalent

Languages
ENGLISH
Level
Excellent

Additional Information

Benefits
  • The financial package will include the monthly researcher allowances subdivided into 1) a living allowance of €3,400 (country correction coefficient applies), 2) a mobility allowance of €600 and, 3) family allowance (€660), if applicable*. Employer costs and other deductions depend on recruiting host.

*If the recruited doctoral candidate has or acquires family obligations during the action duration, i.e. persons linked to him/her by (i) marriage, or (ii) a relationship with equivalent status to a marriage recognised by the legislation of the country or region where this relationship was formalised; or (iii) dependent children who are actually being maintained by the researcher, the family allowance must be paid to him/her as well.

  • Doctoral candidate will be given an employment contract for 36 months by their host institution and will be entitled to full employee benefits and inclusion in social security schemes of the host country.
Eligibility criteria
  • Supported researchers: applicants must be doctoral candidates, i.e., not already in possession of a doctoral degree at the date of recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible.
  • Mobility rule: researchers must not have resided or carried out their main activity (e.g., work, studies) in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before their recruitment date.
  • Other eligibility criteria may apply depending on the recruiting beneficiary.
Selection process

GLYCO-N will select Doctoral Candidates through a 2-step recruitment process (Step 1: evaluation of received documents; Step 2: interviews).

The selection procedure will be open, transparent, and merit-based, fully aligned with the Code of Conduct for the Recruitment of Researchers. Although the selection will be based on the quality of applications, gender balance will also be considered.

Candidates can apply for maximum three PhD projects and the applications need to be submitted separately. All applications will be checked for eligibility. Ineligible or incomplete applications will not be considered.

Additional comments
  • Application Procedure

Applications (in English) must include the following documents in a single PDF file:

  • Letter of motivation addressed to the contact specified under each project in the Offer Description, including a statement why you are suited for this position;
  • Curriculum vitae in EU format, including a photo of the candidate; the CV must be without gaps, in order to easily check the mobility and experience requirements. CVs that either do not clearly show the applicant’s past experience, or have gaps, will be considered ineligible
  • Transcripts of B.Sc and M.Sc. courses, including grades.
  • Copy of master’s thesis (if available). In case the Master’s Degree has not been obtained yet at the closing date for application, the candidate has to submit a declaration signed by their supervisor or University official stating that the degree will be obtained by the time of PhD enrolment.
  • Two references letters from former supervisors, including names, affiliations and email addresses.

Application documents in a single pdf file should be sent by email to the contact specified under the list of each research project in the Offer Description. The subject line of the email must be in the following format: “GLYCO-N: application for Project #_Title of PhD project”.

The candidates will be evaluated on the basis of the received documents (Step 1) against the following criteria:
•    Educational record
•    Scientific quality of the applicant’s CV
•    Expected individual impact and benefit to the fellow and to the project
•    Previous experience in the subject of GLYCO-N research programme

After the Step 1 evaluation, the best 3-4 candidates will be invited for an online interview (Step 2) that will take place in June/July 2024.

A rejection letter will be sent to candidates not selected for the interviews.

The closing date for applications is May 31st, 2024

Planned start date for the doctoral candidates: October, 2024

Work Location(s)

Number of offers available
2
Company/Institute
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Country
Italy
Geofield
Number of offers available
1
Company/Institute
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Country
Spain
Geofield
Number of offers available
1
Company/Institute
DANMARKS TEKNISKE UNIVERSITET
Country
Denmark
Geofield
Number of offers available
1
Company/Institute
UNIVERSITE DE ROUEN NORMANDIE
Country
France
Geofield
Number of offers available
2
Company/Institute
UNIVERSITAET DUISBURG-ESSEN
Country
Germany
Geofield
Number of offers available
1
Company/Institute
IMPERIAL COLLEGE LONDON
Country
United Kingdom
Geofield
Number of offers available
1
Company/Institute
UNIVERSITAT DE BARCELONA
Country
Spain
Geofield

Where to apply

E-mail
molinaro@unina.it

Contact

City
Napoli
Website
Street
Dipartimento di Scienze Chimiche , Complesso Universitario Montesantangelo, Via Cintia 4
Postal Code
80126
E-Mail
molinaro@unina.it