Job Information
- Organisation/Company
- Università degli Studi di Napoli Federico II
- Department
- Chemical Sciences
- Research Field
- Chemistry » Organic chemistryChemistry » BiochemistryPharmacological sciences » PharmacyBiological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Italy
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 36-40
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- HE / MSCA
- Marie Curie Grant Agreement Number
- 101119499
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
- Introduction:
The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop different innovative strategies to 1) understand the diversity and structural complexity of archaeal, microalgal and viral N-glycosylation and 2) harness this knowledge for new solutions in biomedicine and biotechnology.
Protein N-glycosylation, or the attachment of oligo- and polysaccharides at specific asparagine residues, is conserved throughout life, and is now observed even in the viral world. In contrast to most of eukaryotes, whose well-studied N-glycosylation machineries are relatively simple, archaea, microalgae, viruses and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse N-glycans. Because protein N-glycosylation occurs far downstream of protein synthesis the complexity and diversity in N-glycan structures are poorly understood. GLYCO-N program has the bold task to dissect the N-glycosylation pattern harbored by archaea, microalgae and viruses, because aware that any discovery hold promise to shed light in different areas, ranging from drug discovery (antimicrobials) to biotechnology (biologics, glycoprotein and glycoprocessing enzyme engineering for materials and life sciences).
The GLYCO-N network brings together a diverse group of glycobiology researchers with world-leading expertise in carbohydrate chemistry, microbiology, (bio)organic chemistry, computational and structural (glyco-)biology, bioinformatics and chemical biology. The GLYCO-N DCs will have their own individual project with one GLYCO-N expert and will, through research internships, be exposed to complementary Glycoscience.
The selected PhD candidates will experience an international and interdisciplinary training and participate in a series of scientific, technical and complementary skills training events, and secondments to other participating institutions. The position will allow the students to participate in an exciting multidisciplinary research and training programme, enhancing their career perspectives.
- The Glyco-N Consortium
Beneficiaries
The following institutions will directly recruit the DCs:
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II (UNINA), NAPOLI, Italy, Department of Chemical Sciences, Prof. Antonio Molinaro (Coordinator of the GYCO-N project)
UNIVERSITEIT LEIDEN (UL), LEIDEN, Netherlands, Leiden Institute of Chemistry, Prof. Hermen Overkleeft
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS (CIC bioGUNE), DERIO BIZCAYA, Spain, Prof. Prof. Jesús Jiménez-Barbero
UNIVERSITAT DE BARCELONA (UB), BARCELONA, Spain, Department of Chemistry, Prof. Carme Rovira
DANMARKS TEKNISKE UNIVERSITET (DTU), KONGENS LYNGBY, Denmark, Department of Biotechnology and Biomedicine, Prof. Bernard Henrissat
UNIVERSITE DE ROUEN NORMANDIE (URN), MONT SAINT AIGNAN, France, Laboratory GlycoMEV, Prof. Muriel Bardor
UNIVERSITAET DUISBURG-ESSEN (UDE), ESSEN, Germany, Faculty of Chemistry, Prof Bettina Siebers and Prof. Markus Kaiser
Associated Partners with national fundings
The following institution will directly recruit the DCs:
IMPERIAL COLLEGE LONDON (UL), LONDON, UK, Chemistry, Dr. Benjamin Schuman
Associated Partners
The following Institutions and companies are part of the consortium and will contribute to training
activities, including secondments:
Atlas Molecular Pharma S.L. (AMP), Spain, Dr. Oscar Millet
Zelula Biopharma SL (ZB), Spain, Dr. Asís Palazón
Alga Biologics (AB), France, Dr. Catherine Gallot
Samabriva (SAM), France, Dr. Marina Guillet
Isuschem Srl (IC), Italy, Prof. Vincenzo Benessere
Universidad del Pais Vasco (UPV/EHU), Spain, Prof. Dr. Jesús Jiménez-Barbero
Innovation Acta Srl (INN-ACTA), Italy, Dr. Paola Cesaroni
- Research Projects: Applications must be sent by email to the contact specified under the list of each research project
Position | Project title | Host Institution | Reference tutor(s) for PhD application and email |
DC1 | N-glycosylation in the extremophile archaeae | UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II, Italy | Prof. Antonio Molinaro; Prof. Cristina De Castro molinaro@unina.it; decastro@unina.it |
DC2 | Study of the glycosylation machinery of archaea: a new perspective to unravel the evolutionary history of the tree of life | DANMARKS TEKNISKE UNIVERSITET, Denmark | Prof. Bernard Henrissat;
|
DC3 | Study of the function of glycosyltransferases in the crenarchaeal model organism Sulfolobus acidocaldarius to unravel their potential for biotechnological application | UNIVERSITAET DUISBURG-ESSEN, Germany | Prof Bettina Siebers; Bettina.siebers@uni-due.de
|
DC4 | Structure and molecular recognition of viral N-glycoproteins | ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS, Spain | Prof. Jesús Jiménez-Barbero; jjbarbero@cicbiogune.es
|
DC5 | Designer molecules to interfere with host and viral N-glycosylation processing | UNIVERSITEIT LEIDEN, Netherland | Selection closed
|
DC6 | Unraveling the xylosylation pathway of N-glycoproteins in microalgae | UNIVERSITE DE ROUEN NORMANDIE (France) | Prof. Muriel Bardor; muriel.bardor@univ-rouen.fr Dr Elodie Rivet;
|
DC7 | Modeling of mechanisms in wild type and engineered archaeal and microalgal glycoprocessing enzymes for the efficient synthesis of (neo)-glycans | UNIVERSITAT DE BARCELONA, Spain | Prof. Carme Rovira; recruitment.roviralab@gmail.com |
DC8 | Inhibitors and activity-based probes targeting host and viral glycosyltransferases | UNIVERSITEIT LEIDEN, Netherland | Selection closed |
DC9 | Mining chlorovirus PBCV-1 genome to decipher the N-glycosylation biosynthetic pathway | UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II, Italy | Prof. Cristina De Castro; Prof. Antonio Molinaro; decastro@unina.it; molinaro@unina.it
|
DC10 | Development of chemical probes for studying N-glycosylation from bioactive metabolites | UNIVERSITAET DUISBURG-ESSEN, Germany | Prof. Markus Kaiser; markus.kaiser@uni-due.de
|
DC11 | Unraveling how viral glycosylation machineries affect host glycoproteins | Imperial College London, UK | Dr. Benjamin Schumann; ben.schumann@crick.ac.uk To apply, please also check the job position at: |
Additional details on the individual research projects can be found at www.glyco-n.eu or directly asked by email to the reference tutors for the PhD application.
Requirements
- Research Field
- Chemistry » Organic chemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Chemistry » Biochemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Pharmacological sciences » Pharmacy
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
- Applicants must have good knowledge and interest in Carbohydrate chemistry, microbiology, (bio)organic chemistry, computational and structural biology, bioinformatics and chemical biology
- Research experience on these topics is considered an advantage but not mandatory
- Applicants must speak and write fluently in English
Research Field: Chemistry, Organic chemistry, Carbohydrate chemistry, Biochemistry, Structural Biology, Molecular Biology, Pharmacy, Biotechnology
Education Level: Master Degree or equivalent
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
- GLYCO-N DCs will be employed according to the rules for doctoral candidates in MSCA-DCs (https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/…) and the general regulations of each host institution.
- The financial package will include the monthly researcher allowances subdivided into 1) a living allowance of €3,400 (country correction coefficient applies), 2) a mobility allowance of €600 and, 3) a family allowance (€660), if applicable*. Employer costs and other deductions depend on recruiting host.
*If the recruited doctoral candidate has or acquires family obligations during the action duration, i.e. persons linked to him/her by (i) marriage, or (ii) a relationship with equivalent status to a marriage recognised by the legislation of the country or region where this relationship was formalised; or (iii) dependent children who are actually being maintained by the researcher, the family allowance must be paid to him/her as well.
- Doctoral candidate will be given an employment contract for 36 months by their host institution and will be entitled to full employee benefits and inclusion in social security schemes of the host country.
- Supported researchers: applicants must be doctoral candidates, i.e., not already in possession of a doctoral degree at the date of recruitment. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible.
- Mobility rule: researchers must not have resided or carried out their main activity (e.g., work, studies) in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before their recruitment date.
- Other eligibility criteria may apply depending on the recruiting beneficiary.
GLYCO-N will select Doctoral Candidates through a 2-step recruitment process (Step 1: evaluation of received documents; Step 2: interviews).
The selection procedure will be open, transparent, and merit-based, fully aligned with the Code of Conduct for the Recruitment of Researchers. Although the selection will be based on the quality of applications, gender balance will also be considered.
Candidates can apply for maximum three PhD projects and the applications need to be submitted separately. All applications will be checked for eligibility. Ineligible or incomplete applications will not be considered.
- Application Procedure
Applications (in English) must include the following documents in a single PDF file:
- Letter of motivation addressed to the contact specified under each project in the Offer Description, including a statement why you are suited for this position;
- Curriculum vitae in EU format, including a photo of the candidate; the CV must be without gaps, in order to easily check the mobility and experience requirements. CVs that either do not clearly show the applicant’s past experience, or have gaps, will be considered ineligible
- Transcripts of B.Sc and M.Sc. courses, including grades.
- Copy of master’s thesis (if available). In case the Master’s Degree has not been obtained yet at the closing date for application, the candidate has to submit a declaration signed by their supervisor or University official stating that the degree will be obtained by the time of PhD enrolment.
- Two references letters from former supervisors, including names, affiliations and email addresses.
Application documents in a single pdf file should be sent by email to the contact specified under the list of each research project in the Offer Description. The subject line of the email must be in the following format: “GLYCO-N: application for Project #_Title of PhD project”.
The candidates will be evaluated on the basis of the received documents (Step 1) against the following criteria:
• Educational record
• Scientific quality of the applicant’s CV
• Expected individual impact and benefit to the fellow and to the project
• Previous experience in the subject of GLYCO-N research programme
After the Step 1 evaluation, the best 3-4 candidates will be invited for an online interview (Step 2) that will take place in June/July 2024.
A rejection letter will be sent to candidates not selected for the interviews.
The closing date for applications is May 31st, 2024
Planned start date for the doctoral candidates: October, 2024
Work Location(s)
- Number of offers available
- 2
- Company/Institute
- UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
- Country
- Italy
- Geofield
- Number of offers available
- 1
- Company/Institute
- ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
- Country
- Spain
- Geofield
- Number of offers available
- 1
- Company/Institute
- DANMARKS TEKNISKE UNIVERSITET
- Country
- Denmark
- Geofield
- Number of offers available
- 1
- Company/Institute
- UNIVERSITE DE ROUEN NORMANDIE
- Country
- France
- Geofield
- Number of offers available
- 2
- Company/Institute
- UNIVERSITAET DUISBURG-ESSEN
- Country
- Germany
- Geofield
- Number of offers available
- 1
- Company/Institute
- IMPERIAL COLLEGE LONDON
- Country
- United Kingdom
- Geofield
- Number of offers available
- 1
- Company/Institute
- UNIVERSITAT DE BARCELONA
- Country
- Spain
- Geofield
Where to apply
- molinaro@unina.it
Contact
- City
- Napoli
- Website
- Street
- Dipartimento di Scienze Chimiche , Complesso Universitario Montesantangelo, Via Cintia 4
- Postal Code
- 80126
- molinaro@unina.it