- JOB
- Norway
Job Information
- Organisation/Company
- UiT The Arctic University of Norway
- Department
- Department of Research and Development
- Research Field
- Chemistry » Biochemistry
- Researcher Profile
- Recognised Researcher (R2)
- Country
- Norway
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 37.5
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- HE / MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
UiT The Arctic University of Norway has established «The Arctic MSCA-PF program» (uit.no/project/arcticmsca) to recruit excellent young researchers planning to apply for a Marie Skƚodowska-Curie Postdoctoral Fellowship (MSCA-PF) to pursue a career in research. We invite applications from promising young researchers within the field of Biophysical Chemistry and Drug Design. The selected candidate will write a proposal for a 24-month MSCA-PF at UiT together with Professor Richard A. Engh. This is an opportunity to accelerate your research career while living in the urban research city of Tromsø, uniquely located at the top of the world surrounded by some of Europe’s last pristine wild nature.
This call is one of 70 from pre-selected supervisors at UiT The Arctic University of Norway through the “Arctic MSCA-PF program”. Successful postdoc candidates will be invited for a three-day MSCA-PF symposium June 4-6, 2024 (hybrid physical/digital event, see details at uit.no/project/arcticmsca/program-structure). At this event, the candidates will present their past research achievements, discuss future plans with their potential supervisor and learn how to write a successful MSCA-PF application. The selected candidates will, jointly with the supervisor, write the MSCA-PF application by the deadline of September 11, 2024.
In this call we search for talented, young researchers within the field of Biophysical Chemistry and Drug Design as presented by Professor Engh:
Protein kinases are phosphotransfer enzymes that control cell signalling processes. This critical role, along with their “druggable” architecture, has made them one of the most important classes of drug targets. Most approved protein kinase inhibitor drugs have targeted cancers, but the expanding knowledge base of drugs and disease is driving increased interest in new protein kinase targets and new disease areas. We have extensive experimental expertise with AGC and CMGC protein kinases, and an increasing focus on DYRK kinases. These are emerging drug targets in several disease areas, including cancer, metabolic diseases, and especially neurodegenerative diseases, such as Alzheimers Disease. The DYRK kinases are also unusual among protein kinases: their activation mechanism includes the sequence His-Cys-Asp, replacing the otherwise nearly universally conserved {His/Tyr}-Arg-Asp sequence for protein kinases. The replacement of arginine by the redox reactive cysteine residue is particularly interesting for both fundamental and applied research. We use a variety of experimental and computational biophysical methods, including X-ray crystallography, NMR, ITC, MST, and SPR, to study the structural and dynamic properties of DYRK and other exceptional kinases, using purified kinase variants produced by recombinant bacterial expression. The unusual catalytic control structures also present novel opportunities for designing uniquely selective or targeted drugs.
Please send your CV (max 3 pages) and describe a research project that will strengthen and complement the presented research (max 2 pages) to richard.engh@uit.no by Feb 16th 2024. Mark your application "Arctic MSCA". Successful candidates will be contacted in late March 2024.
Where to apply
- richard.engh@uit.no
Requirements
- Research Field
- Chemistry » Biochemistry
- Education Level
- PhD or equivalent
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
- Supported fellows must be in possession of a doctoral degree at the time of the call deadline. Applicants who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree are also eligible to apply.
- At the call deadline, supported researchers must have a maximum of 8 years full-time equivalent experience in research, measured from the date of award of the doctoral degree. Years of experience outside research and career breaks (e.g. due to parental leave), will not count towards the amount of research experience. Find Self-Assessment Tool to calculate your eligibility here.
- Recruited researchers must comply with the following mobility rule: they must not have resided or carried out their main activity (work, studies, etc.) in the country of the beneficiary (for European Postdoctoral Fellowships), or the host organisation for the outgoing phase (for Global Postdoctoral Fellowships) for more than 12 months in the 36 months immediately before the call deadline.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- UiT the Arctic University of Norway
- Country
- Norway
- City
- Tromsø
- Postal Code
- 9019
- Street
- Hansine Hansensvei 18
Contact
- City
- TROMSØ
- Website
- Street
- Hansine Hansensvei 18
- Postal Code
- 9019
- ArcticMSCA@uit.no