- JOB
- Germany
Job Information
- Organisation/Company
- LMU Munich
- Department
- Institute of Ethics, History and Theory of Medicine
- Research Field
- Medical sciences » OtherPhilosophy » EthicsEthics in health sciences » Other
- Researcher Profile
- First Stage Researcher (R1)
- Positions
- PhD Positions
- Country
- Germany
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 38,5
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Marie Curie Grant Agreement Number
- 101120256
- Is the Job related to staff position within a Research Infrastructure?
- Yes
Offer Description
PhD Position in Biomedical Ethics at LMU Munich (Germany)
Modern medicine seeks to personalize diagnosis and treatment to the needs of individual patients. This need is heightened in particular for those individual patients where no treatments are available – and where current standard treatment development paradigms exclude to generate such. The ultimate goal of Medicine made to Measure (MMM) is to go even beyond the latest genetic medicine approaches, implementing a novel paradigm of treatment development: the field of single patient tailored antisense oligonucleotide (ASO) treatments for patients with nano-rare disease mutations. Specifically, MMM will develop core modules of a novel “out-of-the-box”, but still EMA-advised treatment development path for these patients - from omics-based theranostics, via preclinical target validation to innovative trial methodology and a pioneering ethical framework for individualised genetic therapies. MMM provides a unique opportunity for doctoral candidates to be involved in building - and to receive training - in all core modules needed for tailored ASO treatment in Europe. This new scientific field requires a new generation of open-minded, technology-fluent and applications-oriented experts.
MMM will help educate future drug development and translational experts in adopting and disseminating such a cross-specialty approach. Our idea for this innovative training network is built on our personal experience and understanding of the importance of single patient tailored genetic treatments in the years to come. We propose a consortium of world-leading experts and partners that present with extended experience and relevant know-how in molecular biology, neurology, translational medicine, biochemistry, bioinformatics, philosophy, mathematics, regulatory science and engineering.
We offer an attractive education and training programme that extends from engagements in high-level research projects, through tailored and network-wide training modules to providing competencies and skill sets that help young researchers go beyond the specific MMM research paradigm. Thus, MMM provides an exceptional platform to young, ambitious and talented researchers who like to engage in supporting the concept of single patient tailored treatments.
PhD PROJECT: Ethical foundations and implications of tailored genetic treatments
The PhD project aims at establishing a comprehensive ethical framework for the tailored genetic treatment development process. To achieve this goal, the project will (1) define ethical standards for innovative trial types for single-patient genomic medicine (n-of-1 trials; platform, umbrella and basket trials), (2) develop appropriate informed consent procedures based on conceptual analysis and socio-empirical analyses of patients’ informed consent needs, and (3) develop innovative approaches for pricing, coverage, and prioritisation of high-cost/high-effect single-patient ASO treatments.
Where to apply
- Danielle.Ahrendt@med.uni-muenchen.de
Requirements
- Research Field
- Ethics in health sciences » Other
- Education Level
- Master Degree or equivalent
- Research Field
- Philosophy » Ethics
- Education Level
- Master Degree or equivalent
- Research Field
- Medical sciences » Other
- Education Level
- Master Degree or equivalent
Master’s degree qualifying for a PhD and research in the field of biomedical ethics, e.g. philosophy, medicine, health sciences or social sciences. Openness for interdisciplinary research required, some experience with analytical and socio-empirical ethical research methodologies is an advantage.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Ethics in health sciences
Additional Information
Gross salary (without employer’s social contributions) 3942€ per month, plus additional family allowance, if applicable.
Researchers must be doctoral candidates (i.e. not already in possession of a doctoral degree at the date of the recruitment). Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible.
Researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before their date of recruitment. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.
Full applications should include
- A motivation letter
- A Europass CV (https://europa.eu/europass/en)
- Copies of your relevant certificates
- Names and contact details for at least 2 potential referees
Applications should be submitted to Danielle.Ahrendt@med.uni-muenchen.de. For procedural questions, please contact carmen.doerge@med.uni-tuebingen.de.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institute of Ethics, History and Theory of Medicine, Medical Faculty, Ludwig Maximilians University Munich
- Country
- Germany
- City
- Munich
- Geofield
Contact
- City
- Munich
- Website
- Danielle.Ahrendt@med.uni-muenchen.de