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MSCA-DN GlyCanDrug: DC6. PhD scholarship in chemical biology and assay development with focus on inhibitors for glycosyl transferases

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17 Jul 2023

Job Information

Organisation/Company
Technical University of Denmark
Department
Department of Chemistry
Research Field
Chemistry » Organic chemistry
Researcher Profile
First Stage Researcher (R1)
Country
Denmark
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

A PhD studentship in chemical biology of glycosyl transferases funded by the Marie Skłodowska-Curie Doctoral Network GlyCanDrug is available at the Department of Chemistry at The Technical University of Denmark (DTU). The project will be under the supervision of Professor Mads H. Clausen and will start on February 1st 2024 or as soon as possible thereafter. You will join a dynamic research team working at the interface of chemistry and biology.

 

Project Description and responsibilities

The project is entitled Assay development and activity screening of inhibitors of sialyl and fucosyltransferases. It is part of a large European training network GlyCanDrug. This PhD project will focus on the identification of small molecule inhibitors of sialyl and fucosyltransferases. The PhD student will be trained in assay development, miniaturization and automation for high-throughput screening (HTS). An important research goal will be to design and execute an HTS campaign to identify novel putative inhibitors of glycosyl transferases. The PhD student will also characterize known and new transferase inhibitors using fluorescent polarization (FP) assays. Additionally, the chemical synthesis of key reagents needed for assay development and execution will be part of the training. The project is in close collaboration with other group members including synthetic chemists and the screening platform manager.

 

Approval and Enrolment

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education.

 

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

 

Further information

Further questions about the project should be directed to Mads H. Clausen, email: mhc@kemi.dtu.dk.

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark. Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU. 

 

Technology for people

DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

Where to apply

E-mail
glycandrug@chim.unifi.it

Requirements

Research Field
Chemistry » Organic chemistry
Education Level
Master Degree or equivalent
Skills/Qualifications

You should have a two-year master's degree (120 ECTS points, or a similar degree with an academic level equivalent to a two-year master's degree) in synthetic chemistry, medicinal chemistry and/or chemical biology or a related field. Experience with synthetic and analytical organic chemistry is required. Experience with assay technologies is not essential, but a strong desire to learn new techniques in a multidisciplinary environment is crucial. Most importantly, you should be ambitious and highly motivated, able to work independently and should be confident in both written and spoken English.

Languages
ENGLISH
Level
Excellent
Internal Application form(s) needed
GlyCanDrug_Application Form.pdf
English
(180.75 KB - PDF)
Download

Additional Information

Benefits

The salary of the DCs will be paid according to the MSCA rules. See: https://marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-doctoral-networks-2022

Eligibility criteria

The position is open to candidates (of any nationality) that fulfil the requirements set for the DCs funded by MSCA. Equal opportunities policy without distinction on the grounds of gender, racial or ethnic origin, religion or belief, disability, age or sexual orientation will be applied. Eligibility criteria for MSCA-DN researchers https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/… pages 80-82/111

At the time of recruitment applicants must fulfil the following rules:

Experience: eligible applicants must not have a PhD yet, whereas they must have a 5-years degree (Master).

Mobility: the DCs must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years prior to the recruitment date (and not have carried out their main activity (work, studies) in that country).

Selection process

Applicants can apply for up to 3 projects within the consortium, indicating the order of preference. All applications will be checked for eligibility. Incomplete applications will be ignored. Applications must be in English. The applicant must send the following documents (IN A ONE SINGLE PDF FILE) to the email specified (e-mail: glycandrug@chim.unifi.it) within 1st September 2023, clearly indicating in the subject “Application for DCX position”:

1) an updated CV (EU pass format: https://europa.eu/europass/it/create-europass-cv including the details of education/qualifications, work experience, language skills and other relevant skills);

2) a motivation letter (max 1 page);

3) full names, affiliation and email addresses of at least 2 potential referees (at least one of them from one former supervisor and/or lecturer);

4) the scan of the degree (usually the Master Degree) which would formally entitle him/her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send an official declaration of the university stating that the degree will be obtained before the expected starting date and the documents reported at point 5);

5) a certified document indicating the ranking and marks at the Master Degree as well as the courses/modules they have attended. This document is mandatory for applicants who do not have yet obtained the degree at the time of the application.

6) a summary of the Master Degree thesis or a brief description of the past scientific activity.

7) format application. Before the signing of the GA, the format application will be sent to people interested upon request on the email: glycandrug@chim.unifi.it

8) Copy of a valid ID/Passport.

Additional comments

Please note that the application deadline is 1st September 2023 and is different from most other MSCA-DN GlyCanDrug job postings.

Work Location(s)

Number of offers available
1
Company/Institute
Technical University of Denmark, Department of Chemistry
Country
Denmark
City
Kgs. Lyngby
Postal Code
2800
Street
Kemitorvet 207
Geofield

Contact

City
Kgs. Lyngby
Website
Street
Kemitorvet 207
Postal Code
2800
E-Mail
mhc@kemi.dtu.dk

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