- JOB
- Portugal
Job Information
- Organisation/Company
- Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S)
- Department
- Glycobiology in Cancer
- Research Field
- Biological sciences » BiologyChemistry » BiochemistryMedical sciences » Cancer researchEngineering » Biomedical engineering
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Portugal
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 35
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Horizon Europe - MSCA
- Reference Number
- 101119601
- Marie Curie Grant Agreement Number
- 101119601
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
GlyCanDrug is a glycoscience-oriented European Training Network funded in the framework of HORIZON Europe Marie Skłodowska-Curie Doctoral Networks (MSCA-DN). Within GlyCanDrug, Doctoral Candidates (DCs) will be equipped with a thorough multifaceted knowledge of the potential of glycoscience in the discovery of cancer precision therapeutics and the necessary transferable skills. GlyCanDrug will provide an international, intersectoral and interdisciplinary educational program, according with the EU Principles for Innovative Doctoral Training. This will put DCs in an advantageous position for job opportunities in both academia and industry.
DC3 PROJECT TITLE. Evaluation of glycosyltransferases inhibitors and targeted approaches in cancer cells and tumour spheroids.
DC3. This PhD project will focus on the evaluation of the effect of the glycosylation inhibitors in the biosynthesis of key glycan motifs in cancer cells, the targeting of these cancer-associated glycans, and the analysis of the functional effects in the tumor biology and their potential therapeutic applications. With this in mind, the DC will be trained in the cancer glycobiology using advanced glycoengineered models and in glycosylation analytical approaches. The DC will evaluate the effects of the selected inhibitors in the glycan biosynthesis mediated by the targeted enzymes (fucosyltransferases and sialyltransferases), their functional effects in cancer biology and the glycan-based therapeutic efficacy on cancer models.
Host Institution: i3S-Instituto de Investigação e Inovação em Saúde da Universidade do Porto, PORTUGAL. (i3S-University of Porto) https://www.i3s.up.pt/
https://www.i3s.up.pt/research-group.php?groupid=26.
Duration: 36 months, starting between January 2024-November 2024
Supervisor:Celso A. Reis. https://orcid.org/0000-0002-0286-6639
Co-supervisor: Erdmann Rapp (GlyXera, DE), Joana Gomes (i3S, PT), Catarina Gomes (i3S,PT);Progress Committee Members: Celso Reis, Anne Harduin-Lepers, Erdmann Rapp.
PLANNED SECONDMENTS. 1. CNRS (Academia, FR), Glycosyltransferases; 2. GlyXera GmbH (Industry, DE), Glycomics; 3. GD (Industry, DK), Glycan analysis.
PhD School enrolment: Biomedical Sciences at the University of Porto
(https://sigarra.up.pt/icbas/en/cur_geral.cur_view?pv_ano_lectivo=2022&p…)
Where to apply
- glycandrug@chim.unifi.it
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
- Research Field
- Chemistry » Biochemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Medical sciences » Cancer research
- Education Level
- Master Degree or equivalent
- Master Degree in Biochemistry, Biology, Biotechnology, Bioengineering, Medicinal Chemistry or related fields.
- Practical experience in biochemistry, cell biology and/or analytical techniques.
- Good level of English proficiency (understood, spoken and written).
- Team spirit and proactive attitude.
- Languages
- ENGLISH
- Level
- Good
Additional Information
The salary of the DCs will be paid according to the MSCA rules.
See: https://marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-doctoral…;
The position is open to candidates of any nationality, as long as they fulfil the requirements set for the DCs funded by Marie Skłodowska-Curie actions. At the time of recruitment applicants must fulfil the following rules:
- Experience: eligible applicants must not have a PhD yet, whereas they must have a 5-years degree (Master).
- Mobility: the DCs must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years prior to the recruitment date (and not have carried out their main activity (work, studies) in that country).
APPLICATION PROCEDURE
Applicants can apply for up to 3 projects within the consortium, indicating the order of preference. All applications will be checked for eligibility. Incomplete applications will be ignored. Applications must be in English. The applicant must send the following documents to the email specified (e-mail: glycandrug@chim.unifi.it and additionally to email: celsor@i3s.up.pt) within 1st January 2024, clearly indicating in the subject “Application for DC3 position”:
1) an updated CV (EU pass format: https://europa.eu/europass/it/create-europass-cv
including the details of education/qualifications, work experience, language skills and other relevant skills);
2) a motivation letter (max 1 page);
3) full names, affiliation and email addresses of at least 2 potential referees (at least one of them from one former supervisor and/or lecturer);
4) the scan of the degree (usually the Master Degree) which would formally entitle him/her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send an official declaration of the university stating that the degree will be obtained before the expected starting date and the documents reported at point 5);
5) a certified document indicating the ranking and marks at the Master Degree as well as the courses/modules they have attended. This document is mandatory for applicants who do not have yet obtained the degree at the time of the application.
6) a summary of the Master Degree thesis or a brief description of the past scientific activity.
7) format application. Before the signing of the GA, the format application will be sent to people interested upon request on the email: glycandrug@chim.unifi.it
8) Copy of a valid ID/Passport.
ASSESSMENT CRITERIA
Supervisors will pre-select candidates for each position, based on the information included in the application procedure that will be evaluated against the following criteria:
- Educational record;
- scientific quality of the applicant’s CV;
- expected individual impact and benefit to the fellow and to the project;
- previous experience in the subject of the GlyCanDrug research programme.
Shortlisted candidates will be invited for interviews with multiple supervisors from the network (online or in-person). Good level of English proficiency (understood, spoken and written) will be considered. Candidates will be notified of the outcome.
STARTING DATE
Start of employment is foreseen between January-November 2024. The starting date of each PhD contract shall be set according to local rules of the Beneficiary institution and in agreement with the local supervisor of the selected DC project. However, the PhD contract may not begin before the starting date officially established for the GlyCanDrug project, that is 1st December 2023.
The position is open to candidates of any nationality, as long as they fulfil the requirements set for the DCsfunded by MSCA (Annex A). The applicant must send the documents in the Annex A to the email specified (glycandrug@chim.unifi.it) within 1 st January 2024, clearly indicating in the subject “Application for DC3 position”.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- i3S
- Country
- Portugal
- State/Province
- Porto
- City
- Porto
- Postal Code
- 4200-135
- Street
- Rua Alfredo Allen 208
- Geofield
Contact
- City
- Porto
- Website
- Street
- Rua Alfredo Allen 208
- Postal Code
- 4200-135
- rh@i3s.up.pt