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STATUS: EXPIRED
26 Jun 2023

Job Information

Organisation/Company
Institute for Biocomputation and Physics of Complex Systems (BIFI) of the University of Zaragoza
Research Field
Biological sciences » Biological engineering
Chemistry » Biochemistry
Medical sciences » Cancer research
Researcher Profile
First Stage Researcher (R1)
Country
Spain
Application Deadline
Type of Contract
Other
Job Status
Full-time
Hours Per Week
37,5
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

GlyCanDrug is a glycoscience-oriented European Training Network funded in the framework of HORIZONEurope Marie Skłodowska-Curie Doctoral Networks (MSCA-DN). Within GlyCanDrug, Doctoral Candidates(DCs) will be equipped with a thorough multifaceted knowledge of the potential of glycoscience in thediscovery of cancer precision therapeutics and the necessary transferable skills. GlyCanDrug will provide aninternational, intersectoral and interdisciplinary educational program, according with the EU Principles forInnovative Doctoral Training. This will put DCs in an advantageous position for job opportunities in bothacademia and industry.

DC4: Protein expression and purification of FTs and crystallization of FTs and STs complexed to inhibitors. We will express two human fucosyltransferases and two human sialyltransferases involved in cancer progression and metastasis. Our goal is to characterize the inhibitors' biophysical parameters using kinetic and binding experiments, determine their binding modes through co-crystallization, and understand their molecular basis of inhibition. We'll also employ molecular dynamics and docking experiments for inhibitor design based on crystal structures.

Duration: 36 months, starting between January 2024-April 2024. 

Supervisor: Ramon Hurtado Guerrero, https://www.researchgate.net/profile/Ramon-Hurtado-Guerrerohttps://orcid.org/0000-0002-3122-9401

Co-supervisor: 

ProgressCommittee Members: Clausen H.*, Clausen M 

PLANNED SECONDMENTS: 1. DTU-chem, Clausen M, learning how to do HTS of libraries to discover inhibitors for these glycosyltransferases; 2) GD, Clausen H (University of Copenhagen) training in glycoproteomics, genetic targeting of key GT genes.

PhD School enrolment: Biochemistry and Molecular Biology at University of Zaragoza (https://estudios.unizar.es/estudio/ver-doct?id=7073 , https://escueladoctorado.unizar.es/en/doctoral-school-uz-english-content)

 

 

Where to apply

E-mail
glycandrug@chim.unifi.it

Requirements

Research Field
Biological sciences » Biological engineering
Education Level
Master Degree or equivalent
Skills/Qualifications

- Degree (Master) in Biotechnology, Biochemistry, Chemistry, Medicinal Chemistry or related fields.

- We are seeking candidates with expertise in various biophysical techniques, including X-ray crystallography, ITC (isothermal titration calorimetry), thermophoresis, and enzyme kinetics. Expertise in protein expression and purification is also crucial for this position.

- Good level of English proficiency (understood, spoken and written).

- Team spirit and proactive attitude.

Languages
ENGLISH
Level
Good
Research Field
Biological sciences » Biological engineeringChemistry » BiochemistryMedical sciences » Cancer research
Internal Application form(s) needed
GlyCanDrug_Application Form_0.pdf
English
(180.75 KB - PDF)
Download

Additional Information

Benefits

The salary of the DCs will be paid according to the MSCA rules. See:

https://marie-sklodowska-curie-actions.ec.europa.eu/calls/msca-doctoral…

Eligibility criteria

The position is open to candidates (of any nationality) that fulfil the requirements set for the DCs funded byMSCA. Equal opportunities policy without distinction on the grounds of gender, racial or ethnic origin,religion or belief, disability, age or sexual orientation will be applied. Eligibility criteria for MSCA-DNresearchers

https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/

pages 80-82/111

At the time of recruitment applicants must fulfil the following rules:

➢ Experience: eligible applicants must not have a PhD yet, whereas they must have a 5-years degree(Master).

➢ Mobility: the DCs must not have resided in the country where the research training activities will takeplace for more than 12 months in the 3 years prior to the recruitment date (and not have carried out their mainactivity (work, studies) in that country).

Selection process

APPLICATION PROCEDURE

Applicants can apply for up to 3 projects within the consortium, indicating the order of preference. Allapplications will be checked for eligibility. Incomplete applications will be ignored. Applications must be in English. The applicant must send the following documents (IN A ONE SINGLE PDF FILE) to the emailspecified (e-mail:

glycandrug@chim.unifi.it

) within 1st October 2023, clearly indicating in the subject“Application for DC1 position”:

1) an updated CV (EU pass format:

https://europa.eu/europass/it/create-europass-cv

including the details ofeducation/qualifications, work experience, language skills and other relevant skills);

2) a motivation letter (max 1 page);

3) full names, affiliation and email addresses of at least 2 potential referees (at least one of them from oneformer supervisor and/or lecturer);

4) the scan of the degree (usually the Master Degree) which would formally entitle him/her to embark on adoctorate, either in the country in which the degree was obtained or in the country in which the researcher willbe recruited. In case the degree has not been obtained yet, it is necessary to send an official declaration of theuniversity stating that the degree will be obtained before the expected starting date and the documentsreported at point 5);

5) a certified document indicating the ranking and marks at the Master Degree as well as the courses/modulesthey have attended. This document is mandatory for applicants who do not have yet obtained the degree at thetime of the application.

6) a summary of the Master Degree thesis or a brief description of the past scientific activity.

7) format application. Before the signing of the GA, the format application will be sent to people interestedupon request on the email:

glycandrug@chim.unifi.it

8) Copy of a valid ID/Passport.

Additional comments

STARTING DATE

Start of employment is foreseen between January-November 2024. The starting date of each PhD contract shall be set according to local rules of the Beneficiary institution and in agreement with the local supervisor of the selected DC project. However, the PhD contract may not begin before the starting date officially established for the GlyCanDrug project, that is 1st December 2023.

The position is open to candidates of any nationality, as long as they fulfil the requirements set for the DCs funded by MSCA (Annex A).

The applicant must send the documents in the Annex A to the email specified (glycandrug@chim.unifi.it) within1st

October 2023, clearly indicating in the subject “Application for DC4 position”.

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
BIFI of University of Zaragoza
Country
Spain
State/Province
Aragon
City
Zaragoza
Postal Code
50018
Street
Mariano Esquillor, s/n

Contact

State/Province
Aragón/Zaragoza
City
Zaragoza
Website
Street
Mariano Esquillor, s/n
Postal Code
50018
E-Mail
rhurtado@bifi.es
yvergara@bifi.es
Phone
976762997
Mobile Phone
627647624

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