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6 Jun 2023

Job Information

Organisation/Company
Universidad Católica de Valencia
Department
Department of Physiology and Anatomy
Research Field
All
Researcher Profile
First Stage Researcher (R1)
Country
Spain
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Horizon Europe - MSCA
Reference Number
6
Marie Curie Grant Agreement Number
101073316
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

1 Doctoral Candidate position (DC1) at the Universidad Católica de Valencia (UCV) in Valencia, Spain is available in the framework of the Marie Skłodowska Curie - Doctoral Networks (MSCA-DN) project “Targeting RNA as an approach for treating retinal disease” (RETORNA). 

RETORNA proposes breakthrough research, distributed in 10 individual projects, performed by 10 Doctoral candidates (one of them being the DC1), in the following countries: IrelandSpainNetherlandsTürkiyeGermany and Italy. 

DC1 will be hired full time for 36 months by UCV and will work mainly in Valencia, with various secondments in RETORNA consortium.

 

RETORNA summary description:

RETORNA aims to treat retinal diseases (RD) by using RNA therapy. Among the research objectives, we will study different types of RNA that are expressed in retinal cells. By observing bioinformatic models, cell and tissue cultures, animal models, and human patients, we will be able to create RNA profiles for different RD. This screening will identify several targets that will be used as therapeutic approaches. Then, selected RNAs will be used to treat different RD, such as macular degeneration and retinitis pigmentosa.

The proposed doctoral network (DN) will provide an innovative, international, multi/interdisciplinary platform to train young scientists in the field of vision science. 

For more information about RETORNA:

www.retorna.eu

https://cordis.europa.eu/project/id/101073316

 

Please read carefully ALL the details of the individual project DC1 and apply ONLY if really interested!

 

DC1: Micro RNA expression, identification, and functional characterization under oxidative stress challenge in diabetic retinopathy

Host supervisor: Dr. Jorge Barcia González (Universidad Católica de Valencia, Spain)

Objectives:

Recently, the interest on the role of miRNAs in different diseases is rising. These sequences can inhibit the expression of different gene families (antioxidant machinery, inflammation, autophagy…), thus, miRNAs are considered new targets for therapeutic approaches. Dr Jorge Barcia and his team identified several miRNAs expressed by ARPE-19 under oxidative conditions and then studied the potential pathways associated to these miRNAs.

 

Approach:

The present project is based on previous works of the applicant group where cells of the RPE present certain miRNAs (miR-302a, miR-205-5p and miR-122, among others) under-expressed in oxidative stress situations, as occurs in DR and AMD. Furthermore, this downregulation results in an increase of VEGF and therefore in an aggravated growth of retinal capillaries. We propose the use of some miRNAs mimics as antiangiogenic therapy in DR and AMD. The beneficial effect  of miRNAs  miR-302a,  miR-205-5p  and miR-122,  will  be assessed. The latest  miRNAs,  miR-302a and  miR-122,  travel  inside extracellular vesicles (EVs) and will be observed with greater attention, in order to assess whether they could have a potential role as indicators of the advancement of neovascularization or even diagnostic value in the future. Eventually, the study will be completed with experiments using miRNAs silencers. After the in vitro study, selected miRNAs will be analyzed in murine model samples in order to establish a correlation between specific miRNAs and its implication in the retinal neurodegeneration processes. Moreover, experiments with tissue from human patients (DR/AMD) are planned to observe the behaviour of those miRNAs in the eye.

 

Expected Results:

(1) To establish a correlation between specific miRNAs (miR-302a, miR-205-5p and miR-122) and their implication in the retinal neurodegeneration processes

 (2) identify new miRNA targets for therapeutic approaches and/or

(3) identify miRNAs a predictive biomarkers

 

Where to apply

E-mail
andreea.craciun@ucv.es

Requirements

Research Field
Biological sciences
Education Level
Master Degree or equivalent
Skills/Qualifications

Candidates reseachers must:

  • have MSc level training in the fields related to the project 

 

  • possess scientific skills and research experience related to the DC1 project

 

  • necessary skills 
  1. Experience in handling lab animals (or at least willing to learn) 
  2. Cell cultures

 

  • desirable skills: biology lab tecniques, scientific background

 

  • possess a good working level of English: candidates must demonstrate during the interview a good ability to understand and express themselves in both written and spoken English, sufficiently high to fully benefit from the experience 

 

  • be highly motivated to participate in the 3 year programme and commit to obtain the PhD degree

 

  • be available and agree with travelling in the RETORNA consortium for secondments

 

  • possess a high level of independency 

 

Languages
ENGLISH
Level
Good
Research Field
Biological sciencesPharmacological sciencesMedical sciences
Years of Research Experience
None

Additional Information

Benefits

Benefits

RETORNA Doctoral candidate  will be employed according to the rules for Doctoral Candidates in MSCA Doctoral Network and the general regulations of the hosting institution.

The monthly financial package will include the following researcher allowances:

1) Living allowance 

2) Mobility allowance 

3) Family allowance if applicable.

The full-time gross annual salary amounts to € 34.363,56 (family allowance will be calculated only if applicable).

The guaranteed PhD funding is for 36 months starting from 1st of September 2023.

 

Other benefits:

The selected candidate, together with other 9 DCs that will be selected, will benefit from a large variety of activities foreseen for them with costs covered by the Project. DCs at RETORNA will be provided with a unique multi-disciplinary and multi-sectoral training. First and foremost, DCs will be trained as scientists, each of them in their host institution, at their research secondments, and through local and network wide events. Next, thanks to the partnership between academic and non-academic entities, DCs will receive multi-sectoral inputs from both worlds. This will happen via lectures and workshops in our varied training program.

Eligibility criteria

Please read carefully ALL the eligibility criteria and apply only if you possess them:

  • candidates can be of any nationality

 

  • possess a Master degree or an equivalent that allows the access to the doctoral program in the Universidad Católica de Valencia

 

  • not have resided or carried out their main activity (work, studies, etc.) in Spain for more than 12 months in the 3 years immediately before the recruitment date (1st of September 2023). Short stays, such as holidays, are not taken into account.

 

  • be, at the date of recruitment, a doctoral candidate (i.e. not already in possession of a doctoral degree). Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible.

 

  • must comply with the following mobility rule: researchers are required to undertake trans-national mobility (i.e., move from one country to another) and participate in all the activities foreseen by the project when taking up the appointment (trainings, summer courses, annual meetings, lectures, participation in conferences, public activities).

 

 

 

Selection process

The RETORNA selection procedure is open, transparent, merit-based and in line with the Code of Conduct for the Recruitment of Researchers and the European Charter for Researchers.

The criteria for recruitment of DCs will respect the principles of non-discrimination contained in The Charter of Fundamental Rights of the European Union.

It is the policy of the RETORNA project to promote and give equal opportunities regardless of gender and stimulate gender balance.

 

Documents required 

Interested candidates should submit the following documents via email to andreea.craciun@ucv.es, indicating in the e-mail title "RETORNA - DC1 application":

  • a detailed CV, including – if applicable – relevant publications
  • a motivation letter specific for DC1 project, indicating why you wish to conduct this research project
  • transcripts of bachelor and master and the degrees
  • two references names 
  • English certificate if any

All documents must be named as "type of document_Name Surname" (i.e. Motivation letter_Andreea Craciun", "CV Andreea Craciun")

We encourage candidates to send any other certificates, representative publications, academic references or links demostrating the experience and interest in the project. 

 

Additional comments

Selection process

The selection process will foreseen the following steps:

1.  Eligibility: the RETORNA recruitment committee will check that each application is complete and that applicants fulfil the eligibility criteria described in the previous section.

2. Evaluation: each eligible application will be assessed by the principal investigator of our network. The principal investigator will select up to four candidates per position for the following steps:

a. Online interviews: online interviews will be scheduled, in person interview will be organized where possible. Short-listed candidates will be invited for an online interview with the supervisor responsible for the research project. At least one member of the recruitment committee will attend the online interviews.

b. Selection results: our recruitment committee will notify short-listed candidates of the results.

c. Hiring process and enrollment: the selected candidates will be put in touch with the principal investigator and the HR Department of the Universidad Católica de Valencia to initiate the hiring procedure and enrollment.

Applicants who have not been successful but who have received a positive evaluation will be put on a waiting list to cover possible withdrawals and future positions.

Recruitment calendar:

  • Deadline for applications: 14th of June 2023 
  • Eligibility and Evaluation: 15th of June  2023 
  • Online Interviews: 19th of June - 23rd of June 2023
  • Notification to candidates: end of June 2023
  • Hiring process: July - August 2023
  • Start date of the PhD:  1st of September 2023
Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
Universidad Católica de Valencia
Country
Spain
State/Province
Comunidad Valenciana
City
Valencia
Postal Code
46001
Street
Calle Quevedo 2

Contact

State/Province
Spain
City
Valencia
Website
Street
Calle Quevedo 2
Postal Code
46001
E-Mail
andreea.craciun@ucv.es

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