Outline We have evidence in HD that specific amino acid changes in genes of the autophagy pathway lead to early onset of disease. We wish to examine the effects of knocking out the genes containing these changes and to directly model these specific changes in the orthologous proteins in HD mutant...

Outline Cardiff University's Business School, supported by the ESRC Doctoral Training Partnership for Wales (Wales DTP), invites applications for PhD study, with the possibility of being awarded a fully-funded ESRC DTP Studentship, available to start in October 2017. We expect to make doctoral...

Outline The presence of specific APOE alleles confer the highest risk of EOAD in humans, but the mechanisms involved are poorly understood. APOE is a lipid transport protein generated primarily in liver, but also astroglia and microglia. Here, we propose to characterise how the lipid regulatory...

Outline Genome-wide association studies (GWAS) have identified robust risk loci for Alzheimer’s disease (AD). These findings serve as a starting point for novel biological investigation and treatment strategies, once such loci contains the transcription factor MEF2C. This programme has a number of...

Outline Genome-wide association studies (GWAS) have identified robust risk loci for Alzheimer’s disease (AD). These findings serve as a starting point for novel biological investigation and treatment strategies. We have recently identified candidate transcriptional networks that account for a...

Outline This project aims to refine this shared susceptibility into biological processes relevant to specific symptom combinations using novel methods leveraging functional annotations. Genetic overlap between psychiatric and neurological disorders and HD symptoms will be assessed by deriving...

Outline We envisage this project to examine public values in relation to sustainable energy transitions that meet UK climate change and energy security targets. Broadly, the project should build on existing research conducted as part of a Cardiff project funded by the UK Energy Research Centre. See...

Mobility for Regional Excellence MoRE2020 Programme - Call 1: Closed for proposals Region Västra Götaland invites experienced researchers from all nations to submit research proposals to MoRE2020, the Mobility for Regional Excellence Programme. MoRE2020 funds one year collaborative projects between...

Outline The School of Social Sciences, Cardiff University, supported by the ESRC Doctoral Training Partnership for Wales (Wales DTP), invites applications for funded PhD study. These particular studentships, known as ‘collaborative studentships’, involve liaison with a non-academic organisation...

Outline The School of Modern Languages and the Department of Politics & International Relations (IR), supported by the Wales DTP, invite applications for PhD places with the possibility of a fully funded ESRC studentship. The Global Language-based Area Studies (GLAS) pathway, which is hosted by the...