Details
- Deadline
- Research Field
- Formal sciences
- Funding Type
- Funding
- Career Stage
- Recognised Researcher (R2) (PhD holders or equivalent who are not yet fully independent)Established Researcher (R3) (Researchers who have developed a level of independence)
About
MSCA-PF
We are looking for a motivated candidate to submit a postdoctoral MSCA funding application for a duration of 12 to 24 months. The MSCA Postdoctoral Fellowships aim to support the career development of researchers by enhancing their skills diversification at a multidisciplinary level and providing intersectoral experience. The MSCA-PF Fellowship offers a competitive salary, mobility and family allowances (if applicable), as well as funding for research, training, and networking activities. This call for expressions of interest specifically pertains to the European Postdoctoral Fellowships, which involve a duration of 12 to 24 months in Europe. For more information, please visit MSCA-PF website.
The project
A simple method to modify the cell surface would have a significant impact in chemical biology and the field of cell therapy. The covalent grafting of fluorophores, sugar epitopes, peptides, or antibody fragments onto the cell surface, for example, enables in vivo tracking or targeted vectorization in anticancer therapies. Current chemical methods do not address this issue adequately. We recently developed a gentle electrochemical bioconjugation method where cell surface proteins are modified within minutes (see Nat. Commun, 2023, 14, 5122; Chem. Sci., 2021, 12, 15374; J. Amer. Chem. Soc., 2018, 140, 17120). Successfully demonstrated on model cell lines, therapeutic viruses and bacteria, we now aim to demonstrate the relevance of this method for modifying therapeutic cell lines with great potential in anticancer therapies.
We are seeking a candidate interested in the chemistry-biology interface and chemical biology. The jointly developed project will focus on the chemical synthesis of novel coupling compounds and their electrochemical grafting onto cell surfaces.
Ideally, the candidate will have previous experience in bioconjugation, sugar chemistry, or electrochemistry with a good research track.
About the Host
The CEISAM institute (“Interdisciplinary chemistry: Synthesis, Analysis, Modelling”) is located in the University of Nantes and encompasses research activities dedicated to molecular chemistry. The laboratory benefits from cutting-edge equipments for the chemical synthesis and analysis, distributed on a surface area of 3000 sq.m.
Our group has a specific expertise in i) the design of synthetic multivalent inhibitors of pathogenic lectins and glycosidases and ii) the development of new protein bioconjugation methods for remodeling viral, bacterial and cell surfaces, as illustrated by the 60 publications and 8 patents published in the field since 2010.
Web link of the research team:
https://ceisam.univ-nantes.fr/en/corail-team/glycochemistry-bioconjugates/
Eligibility
- Candidates must hold a PhD at the call deadline (11 Sept. 2024) and have 8 years maximum of full-time research experience after the PhD.
- “Mobility rule”: candidates must NOT have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before the call deadline.
Application (CV+Letter of motivation) should be sent to Dr. Sebastien Gouin <sebastien.gouin@univ-nantes.fr> before 30 May 2024.
Organisation
- Organisation Country
The responsibility for the funding offers published on this website, including the funding description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.