Job Information
- Organisation/Company
- integrated Research Training Group "Polymers: random coils and beyond"
- Department
- Faculty of Natural Sciences II, Martin Luther University Halle-Wittenberg
- Research Field
- Physics » BiophysicsPhysics » OtherPhysics » Biophysics
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Germany
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Part-time
- Hours Per Week
- 20
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Doctoral project at the Martin Luther University Halle, Institute of Physics, NMR group (Prof. Kay Saalwächter), starting asap or later in 2023 (subject to negotiations). The research focuses on applications of NMR spectroscopy and complementary techniques to unravel structure and dynamics im macromolecular soft-matter systems. Applicants should have a Master degree (or comparable) in Physics, Chemistry, Polymer Science or a related field, and have prior knowledge of (or strong interest in) soft-matter science, biophysics and/or molecular spectroscopy.
Molecular motion of biopolymers in vivo is known to be strongly influenced by the high concentration of organic matter inside cells, usually referred to as crowding conditions. This project is concerned with the influence of the strong intermolecular interactions on Brownian motion of proteins undergoing liquid-liquid phase separation (LLPS). This is a process of strong current interest due to its high biological relevance, as it yields highly crowded “membraneless organelles”. In the project, a combination of NMR spectroscopy techniques, prominently relaxometry and pulsed-field gradient NMR [1], shall be used to study rotational and translational diffusion, respectively. The work also includes biochemical preparations of proteins (gammaD crystallin and growth factor receptor-bound protein 2, supported by collaboration partners and following standard procedures easily learned also by a physicist), as well as the application of complementary characterization techniques such as small-angle X-ray scattering (SAXS) and viscosity measurements.
[1] J. Am. Chem. Soc. 2016, 138, 32, 10365–10372. https://doi.org/10.1021/jacs.6b06615
Please apply asap via our application portal: https://blogs.urz.uni-halle.de/irtgpolymers/application-webpage/
Requirements
- Research Field
- Physics
- Education Level
- Bachelor Degree or equivalent
Applicants should have – or are about to obtain – a master degree, diploma or an equivalent degree in Natural Sciences or related fields. In general, students hold a degree in physics, chemistry or bioscience. This includes a written thesis, an written or oral test and two years of advanced course work. Degree certificates from non-german universities will have to be approved by the admissions office. Applicants should have a strong interest in the iRTG research program centered on the topic “Polymers: Random coils and beyond” and in cross-disciplinary projects.
Very good command of the English language in reading and writing is mandatory, knowledge of the German language is recommended and helpful, but not mandatory.
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
- exciting projects in fundamental (bio)polymer research
- a supportive and enthusiastic atmosphere
- in-depth training in interdisciplinary soft matter science
- individual supervision and mentoring
- a structured PhD program with seminars and workshops on scientific and transferable skills
- financial support: a working contract with the university (no tuition fee)
- Leipzig and Halle are vital student cities with low cost of living
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- NMR group, Insitute of Physics
- Country
- Germany
- City
- Halle (Saale)
- Postal Code
- 06120
- Street
- Betty-Heimann-Straße 7
- Geofield
Where to apply
- Website
Contact
- City
- Halle (Saale)
- Website
- Street
- Von-Danckelmann-Platz 4
- Postal Code
- 06120