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EURAXESS

12 Marie-Curie PhD positions available - Horizon Europe MSCA Doctoral Network CohesiNet

17 Mar 2023

Job Information

Organisation/Company
CNRS
Department
Biologie
Research Field
Biological sciences
Medical sciences » Medicine
Chemistry » Biochemistry
Researcher Profile
First Stage Researcher (R1)
Country
France
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
38h30
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
HE / MSCA
Marie Curie Grant Agreement Number
101072505
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

We are pleased to advertise 12 positions for doctoral candidates (DCs) to begin in September/October 2023 in many research institutions across Europe, as part of the Horizon Europe Marie Skłodowska-Curie Action Doctoral Network (HE-MSCA DN) of the European Commission entitled “Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases”. The offered positions will all last 36 months and will allow all the recruited researchers to be enrolled in local PhD schools and to participate in an exciting multidisciplinary research programme that will enhance their career perspectives in both the academic and non-academic sector. In addition to their individual projects, all the DCs will benefit from a dedicated training programme consisting of local and network-wide training activities aimed at improving their scientific knowledge and transferable skills.

The CohesiNet consortium includes the following 10 European institutions: 

  • Istituto di Biochimica e Biologia Cellulare del Consiglio Nazionale delle Ricerche (IBBC-CNR), Naples, Italy;
  • MRC Laboratory of Molecular Biology, Cambridge, United Kingdom; 
  • IFOM ETS, Istituto Fondazione di Oncologia Molecolare, Milan, Italy; 
  • Centre de biologie intégrative - Centre National de la Recherche Scientifique (CBI – CNRS), Toulouse, France; 
  • Fundação Calouste Gulbenkian – Instituto Gubenkian de Ciência (FCG - IGC), Oeiras, Portugal;
  • Research Institute of Molecular Pathology (IMP), Vienna, Austria;
  • Lumicks B. V. (LUMICKS) Amsterdam, Netherlands;
  • Amsterdam University Medical Centers (VUMC), Amsterdam, Netherlands;
  • Plasticell Ltd (PLASTICELL), Stevenage, United Kingdom;
  • Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

Project background and aims

Cohesin is an evolutionarily conserved multi-protein complex that belongs to the structural maintenance of chromosomes protein family. It can topologically entrap DNA molecules mediating sister chromatid cohesion, a function important for accurate chromosome segregation and DNA replication/repair. It has been recently discovered that cohesin can generate and maintain DNA loops by an ATPase-dependent in cis DNA tethering activity, called loop-extrusion, critical for organising chromatin architecture and regulating gene transcription, and as such thought to be important for cell differentiation and development. However, the molecular mechanisms by which the cohesin complex achieve these key cellular functions remain to be elucidated. Mutations in genes coding for cohesin and its regulators lead to a class of developmental disorders collectively called “cohesinopathies” and have been found in several types of cancer. Nonetheless, the pathogenesis of these devastating human diseases is poorly understood.

CohesiNet aims to answer outstanding questions in the field of cohesin biology by a highly innovative research programme. This consortium will investigate fundamental mechanisms on how cohesin acts during chromosomal cohesion and loop extrusion, identify regulatory modules of cohesin functions and get insights into the molecular bases of cohesin-related diseases. These ambitious goals will be achieved using multi-disciplinary hypothesis-driven and exploratory approaches while promoting a culture of communication and cooperation among academic and private institutions across the European Union. A team of ten PhD students will be trained by the CohesiNet consortium to address these scientific questions and be empowered with skills that will enhance their career perspectives, while experiencing first-hand the value of Open Science and the importance of inclusion, transparency, accessibility and integrity in scientific research.

Requirements

Research Field
Biological sciences » Biology
Education Level
Master Degree or equivalent
Research Field
Chemistry » Biochemistry
Education Level
Master Degree or equivalent
Research Field
Medical sciences » Medicine
Education Level
Master Degree or equivalent
Skills/Qualifications

Project title: In vivo imaging of cohesin-mediated loop extrusion during DNA double strand break repair

Supervisor: Gaëlle Legube (gaelle.legube@univ-tlse3.fr),Centre de biologie intégrative - Centre National de la Recherche Scientifique (CBI – CNRS)Toulouse, France

Keywords: DSB repair, cohesin dynamics, live-cell imaging, Hi-C

Lab webpage: https://www.legubelab.com

Additional Information

Benefits
  • 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations
  • Monthly living allowance: 3,400 euro/month (€ 40,800/year); this amount is then adjusted through the application of a country correction coefficient to the living allowance of the country in which the researcher is recruited. The country correction coefficients are indicated in Table 1 of the MSCA Work Programme
  • Monthly mobility allowance: 600 euro/month
  • Monthly family allowance, if applicable and depending on the family situation: 660 euro/month
  • Enrollment in a local PhD school 
  • Access to state-of-the-art research and supervision by recognized experts
  • Participation in network-wide training activities, workshops and conferences
  • Secondments periods at other network partners’ labs
Eligibility criteria

Candidates must comply with the following requirements:

  • Have not been resident or have conducted main activity (studies, work, etc.) for more than 12 months within the last three years in the country where the project will take place
  • Have not been awarded a doctoral degree
  • Be fluent in English
Selection process

The selection procedure will consist of the following steps:

  • Eligibility check: The Recruitment Committee will check each application is complete and that applicants fulfil the eligibility criteria described in the previous section.
  • Remote Evaluation: each eligible application will be evaluated independently by the PIs of our network, according to the project options expressed by the applicants. The PIs will select at least four candidates per position to pass through to the following stage.
  • Online interviews: The short-listed candidates will be interviewed by a Selection Committee that will include the recruiting PIs plus one/two additional consortium members with a balance in terms of gender and academic/private sector representation. Candidates, positively evaluated but not initially called for interviews, will be put on a reserve list.
  • Notification of the selection outcomes: Short-listed candidates will be informed about the outcome, and those selected will be put in touch with the corresponding PI and the HR Department of the hosting institution to initiate the hiring procedure. Applicants who have not been successful but who have received a positive evaluation will be put on a waiting list to cover possible renunciations and future positions.

 Recruitment calendar:

  • Call opening: 1st February 2023
  • Deadline for applications: 2nd April 2023
  • Remote evaluation: 3rd – 30th April 2023
  • Interviews: 2nd May 2023 – 20th June 2023
  • Notification to candidates: 30th June 2023
  • Start date of the fellowship: September/October 2023
Additional comments

Candidates are invited to send the following documents to:

gaelle.legube@univ-tlse3.fr

  1. A CV including personal information (such as full name, date of birth, nationality and contact details); education and work experiences language skills and other relevant skills; indication of at least two scientists for reference letters
  2. A certified/signed copy of a recent transcript of exams taken with relative mark. A certified/signed copy of Master of Science certificate. 
  3. List of positions each candidate is interested in. Please choose between 3 (minimum) to 12 positions (if applying to all projects), indicating their order of preference (nr 1 should be the preferred one), using the reference for each project.
  4. Motivation letter (maximum 2 pages) highlighting your research experience and academic achievements and explaining why you are interested in the CohesiNet program and in the selected research projects.

Candidates are encouraged to contact the supervisors by email to discuss the details of the projects, before applying.

Work Location(s)

Number of offers available
1
Company/Institute
CNRS - MCD - CBI
Country
France
City
TOULOUSE
Postal Code
31062 CEDEX 9
Street
118 route de Narbonne

Where to apply

E-mail
gaelle.legube@univ-tlse3.fr

Contact

City
TOULOUSE
Website
Street
118 route de Narbonne
Postal Code
31062
E-Mail
gaelle.legube@univ-tlse3.fr