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EURAXESS

POST-DOCTORAL POSITION IN IMMUNOLOGY OPEN AT CR2TI

Nantes Université
19/08/2022

Job Information

Organisation/Company
Nantes Université
Department
Medecine - Center for Research in Transplantation and Immunology (Inserm )UMR1064
Research Field
Biological sciences
Biological sciences » Biology
Researcher Profile
Recognised Researcher (R2)
Country
France
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
37,15
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

Our team scientific activity is committed to basic and translational research and aims at better understanding the role of Mononuclear Phagocytes (MNP) in inflammatory diseases and in host-virus interactions in the context of transplantation and immunodepression in order to identify new cellular and molecular therapeutic targets. We further developed new functional genomic approaches to better characterize MNP diversity and their role in immunopathology. We showed that the C-type Lectin receptor CLEC-1 acts in MNPs as an immune checkpoint during sterile inflammation (Lopez-Robles et al. Blood Adv 2017) (patent EP16306381). We now aim to study in depth the molecular mechanisms of the CLEC-1 checkpoint in mouse and human MNP in immunopathology by using functional genomics approaches. Pneumonia is currently a major cause of morbidity and mortality worldwide. To date, the most common treatments for pneumonia are antibiotics or antiviral drugs. However, these pathogen-targeted therapies fail to produce favorable results in 10-30% of patients, indicating that additional host-targeted approaches are needed to complement existing therapies. Sepsis causes inflammation and high susceptibility to nosocomial pneumonia by inducing immune defects collectively known as immunosuppression which is notably related to the emergence of myeloid suppressor cells. Our team 1 of CR2TI specialized in MNPs and immunotherapy has previously identified the CLEC-1 receptor expressed by myeloid cells, as a receptor acting as an immune checkpoint. Our team has hypothesized in collaboration with CR2TI team 6, specialized in the impact of inflammation on pulmonary homeostasis, that blocking CLEC-1 may help restore the functions of myeloid cells in patients with pneumonia. Thus, CLEC-1 might represent an original and attractive target to prevent persistent myeloid alterations and deleterious consequences in patients with pneumonia. We propose to 1) decipher the role of CLEC-1 in myeloid cell dysfunction and immune reprogramming during pneumonia by spectral cytometry and scRNA-seq experiments, 2) study CLEC-1 blockade in pre-clinical animal models, and 3) evaluate the clinical relevance of CLEC-1 by studying pneumonia patient samples.

 

Requirements

Research Field
Biological sciences
Education Level
Master Degree or equivalent
Skills/Qualifications

General, theoretical or disciplinary knowledge:

-Expertise in immunology, cell culture, cytometry, and if possible in animal experimentation in rodents and in bioinformatics for sequencing analyses.

- Fluent English, written and spoken.

- Education : MD/PhD or PhD in immunology

- Operational skills:

- Motivation, independent to advance scientific questions.

- Ethical work

- Teamwork, participation in the laboratory day of life, presentation in English at seminars .

Specific Requirements
Activity 1:  The Postdoc will design and implement the experiments for the progression of the project,

Activity 2: - Will critically analyze the data obtained,

Activity 3: - Will generate reports, present in team or Unit meetings in English, at conferences, and will write potential publications, and call for projects.

-Activity 4: - Will supervise undergraduate or graduate students

Languages
ENGLISH
Level
Excellent
Research Field
Biological sciences
Years of Research Experience
1 - 4

Additional Information

Work Location(s)

Number of offers available
1
Company/Institute
Nantes Université
Country
France
State/Province
Pays de la Loire
City
Nantes
Postal Code
44093
Street
30 boulevard Jean Monnet
Geofield

Where to apply

E-mail
Elise.Chiffoleau@univ-nantes.fr

Contact

State/Province
Pays de la Loire
City
Nantes
Website
Street
30 boulevard Jean Monnet
Postal Code
44093
E-Mail
regis.josien@univ-nantes.fr