Job Information
- Organisation/Company
- University of Lille
- Department
- IEMN CNRS
- Research Field
- Physics » BiophysicsEngineering » Microengineering
- Researcher Profile
- First Stage Researcher (R1)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 35
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
One of the main causes of death for cancer patients is organ failure induced by metastasis development. The primary tumor spreads through the body by generating circulating tumor cells (CTCs), that is, cancer cells that detach from the tumor, and extracellular vesicles (exosomes, EV), which circulate within the bloodstream. Our research group at IEMN Lille is partner in an effort to develop an innovative, original family of lab-on-chip (LOC) devices, aimed at detecting CTCs and EVs with high efficiency. The core of the LOC device are DNA aptamers carrying redox species, which detect the presence of a cancer cell immobilized on the chip by quantum-tunneling current fluctuations.
Experimental studies are complemented by two key theoretical and computer modeling pillars:
extensive all-atom molecular simulations, which must characterize the DNA aptamers; their bonding with the electrodes and redox molecules; their dynamical fluctuation trajectory in solution, under realistic conditions; the ligand-receptor interaction between DNA and the protein.
quantum-mechanical electron transport simulations, which use as input the detailed information extracted from the molecular-scale dynamics of the redox species, to calculate the tunneling current as a function of the DNA-protein interaction, to be compared with the experiments
The two coupled theoretical/modeling endeavors constitute the subject of the PhD work, which will be realized in close collaboration with the experimental groups, notably the group in LIMMS/IIS Tokyo (Japan), where short visits may be planned during the course of the PhD. The PhD project has also an underlying, more fundamental motivation in furthering the molecular-scale understanding of the DNA-protein interactions, and quantitatively improving the modeling of electron quantum transport.
Requirements
- Research Field
- Physics » Biophysics
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences » Other
- Education Level
- Master Degree or equivalent
- Research Field
- Mathematics » Computational mathematics
- Education Level
- Master Degree or equivalent
The successful PhD candidate must have a good background in at least three of the following areas: applied mathematics, computational modeling, fundamental physics, biophysics, statistical mechanics, molecular modeling, basic cell biology, bioinformatics.
Working knowledge of Linux/Unix, C/C++/Fortran, Python is a title of preference.
- Languages
- ENGLISH
- Level
- Good
- Languages
- FRENCH
- Level
- Good
Additional Information
Mail your application to the address fabrizio.cleri@univ-lille.fr, including the keyword GRAEL in the mail subject.
Include your CV, titles and grades of the courses followed in the past 2 years (Master), and names/letters of two references. If you had internships, indicate title/place/date and include a brief 1-page summary of the subject.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- IEMN CNRS University of Lille
- Country
- France
- State/Province
- Hauts-de-France
- City
- Villeneuve d'Ascq
- Postal Code
- 59652
- Street
- Av. Poincaré BP 60069
Where to apply
- fabrizio.cleri@univ-lille.fr
Contact
- City
- Villeneuve d'Ascq
- Website
- Street
- Av. Poincaré, Cité scientifique
- Postal Code
- 59652
- fabrizio.cleri@univ-lille.fr
- Phone
- +33320197928