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EURAXESS

Postdoc on massive diversity generation: from evolution to design (M/F)

CNRS - National Center for Scientific Research The Human Resources Strategy for Researchers
5 Apr 2024

Job Information

Organisation/Company
CNRS
Department
Laboratoire de physique de l'ENS
Research Field
Physics
Researcher Profile
First Stage Researcher (R1)
Country
France
Application Deadline
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
35
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

The aim of this postdoc is to computationally understand and model the efficiency of the Diversity Generating Retroelements (DGR) system used by phages and certain bacteria to diversify their proteins. This theoretical understanding will then be used in collaboration with David Bikard's group (Institut Pasteur) to generate new variants of the Cas9 protein.

The postdoc, based at LPENS, will be responsible for developing models based on sequence data and mutation probabilities performed by the DGR retropolymerase system to find the best DNA sequences for generating new proteins. He/she will work closely with the Institut Pasteur experimental group.

The young researcher will work at LPENS, and will frequently visit the Institut Pasteur.

Requirements

Research Field
Physics
Education Level
PhD or equivalent
Languages
FRENCH
Level
Basic
Research Field
Physics
Years of Research Experience
None

Additional Information

Eligibility criteria

- advanced level in statistical physics/out-of-equilibrium processes
- basic knowledges in bioinformatics

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
Laboratoire de physique de l'ENS
Country
France
City
PARIS 05
Geofield

Contact

City
PARIS 05