Post-doctoral/researcher postion in Phylogenetic Sysstems Necrosciences (ref 260792)

About the project: Autophagy as a phylogenetically conserved mediator of sleep benefits

Our overarching hypothesis is that some health benefits linked to sleep are dependent on functional autophagy. We propose to (1) elucidate the specific function of autophagy during sleep in order to (2) manipulate autophagy to reverse the neural effects of subpar sleep. The Boccara and Knævelsrud labs are uniquely positioned to tackle this question by combining the advanced sleep recording and sleep modulating tools developed in the Boccara lab with the autophagy tools developed in the Knævelsrud lab. In this joint project, we will develop tools and strategies to study autophagy during sleep in an invertebrate (Drosophila) and a rodent (rat) model of sleep deprivation. Our ambition is to highlight autophagy as a phylogenetically conserved mediator of sleep-benefits at a cellular level – thus opening very concrete new translational avenues for much needed therapeutic applications.

We seek a highly motivated postdoctoral candidate with either experience in (i) in vivo electrophysiology and/or in (ii) autophagy in a physiological context. The selected candidate will work at the intersection of cell biology, physiology, and systems neuroscience, gaining a unique holistic perspective on autophagy and sleep. Under the supervision of Boccara (Norwegian Centre for Molecular Medicine – ERC 2023 – Nature Comm 2022, Science 2019) and Knævelsrud (Institute for Basic medical sciences – ERC 2022 – iScience 2023, Nature Comm 2016), the postdoc will be introduced to the forefront of promising research fields and cutting-edge techniques, making their profile extremely attractive for future recruitments. Both groups are composed of scientists from diverse backgrounds, allowing exchange of ideas across disciplines. At NCMM the postdoc will be exposed to various methods in molecular and precision medicine, whereas at IMB/OUS they will be part of the membrane dynamics unit within the Division of Biochemistry.

For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/260792/post-doctoral-researcher-position-in-phylogenetic-systems-neurosciences-at-the-universty-of-oslo