Post-doc in cell biology and mechanobiology (M/F)

The candidate will join the team "Phagocyte architecture and dynamics" at the IPBS. He/she will develop a research project aiming at understanding the mechanical functioning of phagocytosis. This study will be carried out under the supervision of Renaud Poincloux.

The postdoctoral fellow will be in charge of the development of the project and will adopt a multidisciplinary strategy combining cell biology approaches, force measurements, quantitative 3D imaging and cryo-electron tomography. He/she will design, implement and interpret the experiments. For this, he/she will work independently but also with other team members and collaborators for the needs of the project. He/she will participate in the dissemination and valorization of the results and will carry out the bibliographic watch of the field.

The project will be developed at the IPBS, which is a Joint Research Unit of the CNRS and the Paul Sabatier University (University of Toulouse). The main objective of the IPBS is the identification, characterization and exploitation of new therapeutic targets in the fields of cancer, infection and inflammation. The postdoctoral fellow will join the team led by Renaud Poincloux and Christel Vérollet, which studies the interactions between phagocytes and their environment, in physiological and pathological contexts.

6 recent publications of the team :

Mascarau M et al. (2023) Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells. J Cell Biol
Portes M et al. (2022) Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts. Elife
Jasnin M et al. (2022) Elasticity of dense actin networks produces nanonewton protrusive forces. Nat Commun
Dupont M et al. (2020) Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. Elife
Souriant S et al. (2019) Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages. Cell Rep
Raynaud-Messina B et al. (2018) The bone degradation machinery of osteoclasts: a novel HIV-1 target that contributes to bone loss. Proc Natl Acad Sci USA