Postdoctoral Position : Organic Chemistry – Isotope Labeling

Labeling of organic compounds with b^- emitting isotopes has a remarkable impact on public health and particularly on the collection of ADME data. While radiolabeling of organic molecules has witnessed major attention, late-stage access still represents a challenge. Within the ERC project FASTLabEx, we aim to develop novel methodologies for the effective late-stage labeling of complex pharmaceutically active molecules. The project will explore new methodologies using primary carbon-labeled building blocks (CO₂, CO, etc). The use of transition metal catalysis (Pd, Ni etc) and photocatalysis will be explored.

The postdoctoral fellow will be hosted in the Laboratory of Isotope Labeling (CEA), which has an established expertise in metal catalysis, photoredox chemistry and isotope labeling. All experiments will be conducted with stable carbon-13. CEA personnel will perform experiments with carbon-14.

References:

-For recent publication from our laboratory, see: J. Am. Chem. Soc. 2024, 146, 8343−8351, J. Am. Chem. Soc. 2023, 145, 30, 16760–16770, Nat. Commun.2023, 14, 4451, J. Am. Chem. Soc.2021, 143, 5659–5665;ACS Catal. 2021, 11, 2968−2976; Chem. Commun., 2020, 56, 11677-11680; Angew. Chem. Int. Ed. 2020, 59, 13490 –13495;J. Am. Chem. Soc. 2019, 141, 780-784;Angew. Chem. Int. Ed. 2018, 57, 9744.