Search position : Controlled "Hot Nano-SPots" ThroUgh NanopaRticle-Assisted Heating and Luminescent Thermometry

We propose a conceptually new approach to the NP-assisted heating/hyperthermia based on a deep understanding of a heat transfer at nanoscale and a precise temperature readout permitting to optimized and controlled “hot spots” effect triggered by magnetic field or light irradiation, which will be more efficient than macroscopic heating of the whole solution due to its very localized character.

Main mission and activities:

i) design heater@thermometer NP by using Fe3O4 NP as nanoheater core enwrapped by silica shell of different thickness containing emissive temperature sensors: sensor 1 integrated in the silica pores to give the readout of the surface temperature and sensor 2 attached on the surface at fixed distance to measure the temperature at the nanoscale distance from the surface.

(ii) to demonstrate the “hot spot” effect through the measurements of temperatures, under external activation (light irradiation or magnetic field) in the shell and at a fixed nanoscale distance from the NP’ surface.

(iii) to demonstrate the “hot spot” hyperthermia with intracellular thermometry on cancer cells.

Synthesis of core@shell inorganic nanoparticles. Synthesis of lanthanide based clusters. Encapsulation of lanthanide-based clusters and surface functionalisation of the as-obtained nanoparticles. Conduct experiments of temperature measurements under external stimuli.