Tissuloid model for studying tissue self-organization

Project summary:

Tissue formation is a highly regulated morphogenetic process, involving iterative interactions among cells and cell groups, guiding cellular differentiation and patterning on a large scale. This complex, yet not well-understood, emergent phenomenon enables individual cells to self-organize into intricate macroscopic structures. The dysfunction of tissue morphogenesis is implicated in various pathologies, including cancer.

In our team, we are developing an original approach to create a pattern of macroscopic tissue-like structures, which we have named tissuloids, from single cell populations. This technology offers a unique opportunity to explore self-organization processes at every scale, from the micro (cell) to the macro (tissue) level.

As we embark on this new project to investigate the mechanisms of tissue morphogenesis and pathology, we are seeking a motivated PhD candidate to join us in unravelling the mysteries of tissue self-organization. In this role, you will tackle fundamental questions such as: How do the mechanical properties of the microenvironment influence cellular behaviour? How do changes at the cellular level manifest in tissue patterning? What role do emergent phenomena play in this complex process?

Student role: As part of our team, you will characterize the mechanical properties of extracellular matrices and cells, investigate the forces exerted by cells and cell assemblies, analyze the dynamics of tissuloid assembly, and decipher the mechanical and biochemical signals involved. You will utilize the newest technologies in 3D cell culture, mechanobiology, and imaging to make an impact in the fields of tissue engineering and translational research.

Funding category: Contrat doctoral

GRAL fellowship for funding as a Laboratoire d’excellence (Labex) through the “Investissements d’avenir”

PHD Country: France