Postdoc in computational biology on tumor heterogeneity (ref 259648)

The Sveen group is part of an interdisciplinary translational research program for colorectal cancer at OUS. An overarching theme of our research is to model tumor heterogeneity and its clinical impact based on DNA/RNA sequencing of multiple tissue samples from primary and metastatic tumors. We also have a platform for drug screening of pre-clinical models, and we integrate molecular and pharmacological data to develop new precision cancer medicine strategies.

The Kuijjer group was established in 2018 and focuses on developing computational and data science approaches to expand our understanding of gene regulation and how rewiring of gene regulatory networks can influence cancer development, progression, and disease heterogeneity. Amongst others, the group's current projects leverage approaches from network science and machine learning in tool development for (1) modeling of regulatory interactions at bulk and single-cell resolution, (2) integration of regulatory networks with multi-omics data, (3) fine-tuned analysis of genome-wide regulatory networks. The group applies these tools to study solid tumors, including colorectal cancer in this project.

The joint project aims to identify the regulatory mechanisms of spatiotemporal tumor heterogeneity in colorectal cancer. The selected candidate will apply and combine computational tools to model gene regulatory networks in transcriptomics data. Tumor heterogeneity will be evaluated in multiregional samples of primary tumors and in multiple metastases from each patient. Drug target potential will be analyzed in a living biobank of tumor organoids screened for sensitivity to anticancer drugs. The proposed postdoc candidate will be trained in computational analyses and collaborate in an interdisciplinary translational research environment with bioinformaticians, molecular biologists, cell biologists, and clinical researchers. All needed infrastructure is established, and computational tools and molecular data are available.

For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/259648/postdoc-in-computational-biology-on-tumor-heterogeneity