Job Information
- Organisation/Company
- CNRS CBMN UMR 5248
- Research Field
- Chemistry
- Researcher Profile
- Recognised Researcher (R2)Leading Researcher (R4)First Stage Researcher (R1)Established Researcher (R3)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
The discovery of liposomes more than 60 years ago predicted a paradigm shift in the design and administration of future drugs using nanotechnologies. However, despite their undeniable advantages (e.g., increased biocompatibility, modularity, versatility of payloads, etc.), this vectorization system still suffers from an early loss of their cargo, limiting its popularization in clinics.
Supported in its 1st phase by the Initiative of Excellence (IdEx - Univ Bordeaux; NanoPRECOS project), our group has recently validated a proof of concept to improve the stability of amphiphilic nanoparticles (e.g. liposomes) through a simple and effective approach: we have designed and synthesized bola-amphiphiles as key compounds to be incorporated in amphiphilic drug delivery systems (DDS), like bolasomes. The current doctoral project aims to optimize the bolas identified previously in the laboratory in order to bring this technology to a clinical application in cancer therapy. Several chemical modifications are to be investigated in order to target: (1) a sustained-drug release (2) a stimuli-triggered drug release (e.g. light, pH, etc.).
The current PhD project (Design of smart SUstained-RElease drug delivery systems: synthesis, characterization and applications in nano-medicines - NANO-SURE) is being developed in collaboration with our national partners (IECB, BRIC - Bordeaux) and international partners (Phospholipid Research Center - Germany).
Bibliography:
Wires nanomed nanobiotechnol (2017) 9:e1450. doi: 10.1002/wnan.1450
Micromachines 13 (2022) 1623, doi:10.3390/mi13101623
Nature Communications 14 (2023) 6659, doi: 10.1038/s41467-023-41946-8
Journal of Colloid and Interface Science 653 (2024) 1792, doi:10.1016/j.jcis.2023.09.195
Funding category: Contrat doctoral
secured MESRI Scholarship
PHD title: PhD in Medicinal Chemistry
PHD Country: France
Requirements
The doctoral candidate should have undeniable qualities in organic chemistry. A multi-step approach is envisaged to access targeted molecules, involving standard methods of heterocyclic chemistry, organometallic chemistry, peptide couplings, etc. The ability to acquire new techniques in analytical chemistry, formulation and characterization of nano-assemblies (HPLC, DLS, FCS, cryo-TEM, etc.) is also essential for the success of the project. The choice of molecules to be synthesized will be guided by molecular modeling studies (coarse-grained molecular dynamics) conducted by our group.
Activities:
multi-step organic synthesis (Michel additions, heterocyclic chemistry, organometallic chemistry, amphiphilic chemistry, orthogonal protective groups, fluorophores, etc.); analytical characterization of the synthesized chemicals: NMR, MS, IR, UV/Vis, Fluorescence spectroscopy, HPLC); bibliography; regular reports and work-in-progress meetings in English; scientific article writing.
Skills:
- organic chemistry: multistep synthetic chemistry
- analytical chemistry: NMR, MS, IR, UV/Vis, FS, HPLC
- professional English necessary to work in an international environment
Salary:
- approx. 1700 eur net / month (the funding was already secured by the host group)
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- CNRS CBMN UMR 5248
- Country
- France
Where to apply
- Website
Contact
- Website