Job Information
- Organisation/Company
- LSO Ecole Polytechnique
- Research Field
- Chemistry
- Researcher Profile
- Recognised Researcher (R2)Leading Researcher (R4)First Stage Researcher (R1)Established Researcher (R3)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Nitrogen‑containing heterocycles display better interactions with biological targets and therefore are prone to be effective pharmacological agents [1]. In our research group, we focus on the development of original transformations relying on cycloaddition strategies towards the rapid construction of azacycles. [2]
In this context, this project aims to investigate the reactivity of readily available precursors of 1,4 nitrogenated zwitterionic dipoles via a palladium-catalyzed decarboxylative process. These transient species will be engaged in (4+2) cycloadditions to furnish six-membered heterocycles. This underexploited strategy will allow to control the regio- and diastereoselective outcome of the transformation through a screening of the palladium ligands. Chiral ligands will also be examined to access enantioenriched structures.
1) Njardarson et al. J. Chem. Ed. 2010, 87, 1348
2) Anaïs Scuiller, Nicolas Casaretto, and Alexis Archambeau, J. Org. Chem. 2023, 88, 9941−9945.
Antoine Roblin, Nicolas Casaretto, and Alexis Archambeau, Org. Lett. 2023, 25, 6453−6458
Funding category: Contrat doctoral
PHD title: Doctorat de Chimie
PHD Country: France
Requirements
The applicant must have a strong background in the field of organic chemistry, organometallic catalysis and knowledge of good laboratory practice.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- LSO Ecole Polytechnique
- Country
- France
- City
- palaiseau
Where to apply
- Website