Job Information
- Organisation/Company
- University Medical Center Utrecht (UMC Utrecht)
- Research Field
- Medical sciences
- Researcher Profile
- Recognised Researcher (R2)
- Country
- Netherlands
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Not Applicable
- Hours Per Week
- 36.0
- Is the job funded through the EU Research Framework Programme?
- Not funded by an EU programme
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Our research aims to understand mechanisms of chronic pain. We specifically focus on the communication between the immune and nervous system and mitochondria. We recently discovered that mitochondria are important in regulating pain. Mitochondria not only regulate sensory neuron function, macrophages also donate their mitochondria to sensory neurons to control pain. In addition, we have found that a mitochondrial methyltransferase pain protein promotes chronic pain development. In this 2-year project you will investigate downstream targets of this protein in sensory neurons and macrophages/microglia using in vitro and in vivo strategies. You will use different molecular approaches including high-resolution mass spectrometry-based proteomics. In addition you will perform functional in vitro assays, such as assessment of macrophage function and mitochondrial activity in sensory neurons to assess identified targets. Finally you will aid with in vivo gene targeting strategies to assess the contribution of the target protein in regulation of chronic pain in different murine pain models.
Requirements
We are looking for talented and highly motivated research technician with a HBO degree in laboratory sciences, with expertise in molecular biology. You have excellent experimental skills and experience in cloning, cell culture, flow cytometry, ELISA’s and immunoprecipitation experiments. Affinity with neuro-immunology, molecular techniques, and mitochondrial assays is a plus. The willingness and certification to perform animal experiments is not a requirement, but would be appreciated. You should have good communication skills, flexible and good team player.
You should have good communication skills, organizational talent, flexible, versatile and a good team player.
Your application should include a motivation letter, a CV, and a brief description of past work experience.
Additional Information
The maximum salary for this position (28 - 36 hours) is € 4.052,00 gross per month based on full-time employment.
In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).
Contact our colleague:
Niels Eijkelkamp
088 75 543 54
n.eijkelkamp@umcutrecht.nl
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- UMC Utrecht
- Country
- Netherlands
- City
- Utrecht
- Postal Code
- 3584CX
- Street
- Heidelberglaan 100
- Geofield
Where to apply
- Website
Contact
- City
- Utrecht
- Website
- Street
- Heidelberglaan 100
- Postal Code
- 3584 CX