Post-Doctoral Fellowship in Biochemistry / Molecular and Cell Biology

This project to be developed at the University of São Paulo's São Carlos Institute of Physics (IFSC-USP) in Brazil aims to study the in situ structure of mitochondrial filamentous enzymes involved in the metabolic adaptation of tumors and their effects on organelle ultrastructure and morphology upon filamentation. This research will be an extension of Adamoski et al, NSMB 2024 (doi: 10.1038/s41594-023-01118-0), focusing on more profound questions with cutting-edge methodologies, such as correlative light-electron microscopy (CLEM), cryo-electron tomography in lamella (cryo-ET) and expansion microscopy (ExM), that can be also applied to other proteins in the lab.

Methodological Responsibilities:

1) Sample Preparation: Engage in cell culturing, vitrification, and lamellae preparation in our lab, at the IFSC/USP;
2) Data Collection and Processing: Perform high-resolution tomographic data collection using top-tier microscopy facilities in Brazil and internationally. Data processing will be done in-house.

Requirements:

1) PhD in Chemistry, Biochemistry, Molecular Biology, or related;
2) Experience in Cell Biology; proficiency in cryo-FIB and cryo-ET, or single-particle cryo-EM is a plus; 
3) Strong analytical, collaboration, and English language skills.

Details and how to apply: https://www.ifsc.usp.br/alba/fapesp-postdoctoral-position-on-in-situ-cryo-electron-tomography/.

This opportunity is open to candidates of any nationality. The selected candidate will receive a Post-Doctoral fellowship from the São Paulo Research Foundation (FAPESP) in the amount of R$ 9,047.40 monthly and a research contingency fund, equivalent to 10% of the annual value of the fellowship which should be spent on items directly related to the research activity. 
 
More information about the fellowship is at: fapesp.br/oportunidades/6788.