PhD position - Designing stable chaperone platforms: from evolution to innovation

Annotation of the dissertation topic: Join my research group in an exciting venture to develop new molecular platforms for detection and therapy, leveraging the potential of chaperone domains. This PhD project is at the forefront of molecular innovation, focusing on stabilizing these platforms for library construction and therapeutic applications. Your work will contribute to the development of novel molecular platforms with potential applications in detection and therapy, bridging the gap between basic molecular biology and applied biomedical research. As a PhD candidate, you will be actively involved in experimental design, data collection, analysis, and interpretation. You will have the opportunity to work with advanced technologies and contribute significantly to a rapidly evolving field. You will employ a range of cutting-edge techniques including evolutionary analysis, protein crystallization, and structural characterization using the synchrotron source.

Project goals:

1) Explore natural hyperstable chaperone domains and identify stabilization hotspots through comparative evolutionary analysis.

2) Investigate mesophilic and psychrophilic variants of chaperone domains from bacteria adapted to low-temperature environments.

3) Conduct functional analysis and crystallization of new chaperone domains and variants.