PhD position - Exploring the frontiers of protein dynamics: from crystallography to ultrafast spectroscopy

Annotation of the dissertation topic:

Join our cutting-edge research project aimed at unraveling the intricate world of protein structures and dynamics. This PhD opportunity will immerse you in the fascinating realm of protein crystallography and advanced spectroscopic techniques. You will be at the forefront of employing state-of-the-art methodologies to delve into protein-ligand interactions, protein quakes, and crucial enzymatic processes like proton and electron transfers. As a PhD candidate, you will be instrumental in conducting these sophisticated experiments, analyzing data, and contributing to the field's knowledge. This project offers a unique interdisciplinary and international experience between Košice(SK)•Prague(CZ)•Paris, (FR), bridging the gap between structural biology, biophysics, and chemistry. Your research could pave the way for groundbreaking advancements in understanding protein mechanisms, potentially leading to novel therapeutic approaches.

Project goals:

1) Determine the three-dimensional structures of novel protein domains, including new chaperone domains of Hsp70.

2) Investigate human pathological immunoglobulin light chains in complex with emerging therapeutics.

3) Apply ultrafast optical spectroscopies and time-resolved X-ray techniques to study enzyme catalysis and other dynamic processes.