PhD position - Deciphering the mechanisms of pathological IgG aggregation in oncohematological diseases

This PhD project offers a unique opportunity to delve into the molecular intricacies of oncohematological diseases like multiple myeloma and light chain amyloidosis. These conditions, marked by the aggregation of pathological immunoglobulin G (IgG) light chains, lead to severe health complications and are currently classified as incurable. You will employ a range of structural and biophysical techniques to study these processes ex vivo, gaining insights into the complex mechanisms at play in these diseases. Your work will contribute to a deeper understanding of the aggregation mechanisms of pathological IgGs, potentially leading to new therapeutic strategies for these challenging conditions. As a PhD candidate, you will be actively involved in experimental design, data collection, and analysis. You will also examine the role of chaperone domains as potential binders and therapeutic agents. This project presents a significant opportunity to contribute to a field of high medical importance.

Project goals:

1) Investigate the biological and biochemical factors contributing to the aggregation of pathological IgG light chains.

2) Explore the interactions between serum proteins, lipid vesicles, and cell surface properties that catalyze or drive this aggregation process.

3) Examine the application of chaperone domains as potential disaggregation drugs.