Job Information
- Organisation/Company
- IGDR
- Research Field
- Biological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 36.5
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- H2020 / Marie Skłodowska-Curie Actions
- Marie Curie Grant Agreement Number
- 101119504
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
The apical membrane of the intestinal epithelium presents a network of actin-based microvilli, called the brush border, which is essential for food absorption, mucus secretion and interactions with the microbiome. In this project, we propose to molecularly characterize microvilli growth and maintenance in a living organism, using C. elegans as a model.
We recently started to describe the growth and dynamics of microvilli during C. elegans development (Bidaud-Meynard et al, 2021 PMID: 34704594). We will next characterize how major microvilli components contribute to microvilli growth and maintenance by using loss of function approaches and a combination of super-resolution imaging, FRAP measurements and food absorption experiments. We will investigate the role of microvilli factors that we and others have already identified, as well as new microvilli components identified by our collaborator Mike Boxem (Utrecht University, Netherlands) using a proteomic approach. This project will lead to the first in-depth functional characterization of microvilli growth and maintenance in a living organism, paving the way to future studies as a model for human intestinal diseases.
Keywords: Intestine - Microvilli - Actin - Microscopy
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
Candidates must hold a Master degree in Cell Biology or Developmental Biology
Candidates must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before their date of recruitment.
- Languages
- ENGLISH
- Level
- Good
Additional Information
The Marie Skłodowska-Curie Doctoral Networks Programme offers highly competitive and attractive salary and working conditions. Each fellowship includes the following:
- Monthly living allowance: 3,400 euro/month (€40,800/year); this amount is then adjusted through the application of a country correction coefficient to the living allowance of the country in which the researcher is recruited. The country correction coefficients are indicated in Table 2 of the MSCA Work Programme.
- Monthly mobility allowance: 600 euro/month
- Monthly family allowance, if applicable and depending on the family situation: 660 euro/month.
Candidates should hold a Master degree in developmental biology or cell biology; French speaking is not required. Send a CV, a motivation letter and the name of 2 references to anne.pacquelet@univ-rennes.fr or gregoire.michaux@univ-rennes.fr.
The successful applicants will be able to closely collaborate with the SurfEx teams of Mike Boxem, Lukas Kapitein and Silvia Mihăilă from Utrecht University; Fernando Martin Belmonte from CSIC; Mikael Sellin from Uppsala University; Thaher Pelaseyed from University of Gothenburg; Daniela Pacheco from Bac3Gel® Lda; Martin Knight from Queen Mary University of London; Daniel St Johnston from the University of Cambridge. They will also be integrated in the IGDR PhD program.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- IGDR
- Country
- France
- Postal Code
- 35000
- Street
- 2 avenue du Professeur Léon Bernard
- Geofield
Where to apply
- anne.pacquelet@univ-rennes.fr
Contact
- City
- Rennes
- Website
- Street
- 2 avenue du Professeur Léon Bernard
- Postal Code
- 35043