Postdoctoral fellow in cancer research with focus on extracellular vesicles

The University of Gothenburg tackles society’s challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

The Institute of Clinical Sciences is one of six Institutes within Sahlgrenska Academy at the University of Gothenburg. We conduct research and education that puts people's health and quality of life in focus. We represent 16 different research areas and are divided into four sections. Through a fruitful collaboration with the healthcare and Sahlgrenska University Hospital, we have developed joint projects and meeting places that benefits both health care and research.

The Institute of Clinical Sciences, Department of surgery, is now searching for a postdoctoral fellow to work with preclinical research, mainly concerning extracellular vesicles and cancer. The newly established research group of Rossella Crescitelli conducts translational research in extracellular vesicle field (https://www.gu.se/om-universitetet/hitta-person/rossellacrescitelli). The research group is based at the Institute of Clinical Sciences, but also belongs to the Wallenberg Center for Molecular and Translational Medicine (WCMTM) and Sahlgrenska Center for Cancer Research (SCCR), which provides good opportunities for career development and network building. WCMTM and SCCR consist of a large network of research group leaders and their team members within the University of Gothenburg and also well-functioning national collaborations. Moreover, the research group has access to Krefting Research Center, an exceptionally well-equipped center for research in the field of extracellular vesicles. More information about ongoing research activities and key research groups within Wallenberg Center for Molecular and Translational Medicine, Sahlgrenska Center for Cancer Research and Krefting Research Centre can be found at www.wcmtm.gu.se, https://www.gu.se/en/cancercenter; https://www.gu.se/en/krefting-research.

Subject area 

Extracellular vesicles and Cancer Research 

Subject area description 

The project will elucidate how extracellular vesicles (EVs) mediate communication between cells in the tumor microenvironment. The overall aim of this project is to reveal novel extracellular vesicle-mediated mechanisms of cancer growth and progression. We have recently developed a state-of-the-art method to isolate highly purified EVs directly from tissue (Crescitelli R, Nature Protocols, 2021 https://www.nature.com/articles/s41596-020-00466-1). The postdoctoral fellow will utilize this novel technology to explore and describe EV-mediated communication between cells in the tumor microenvironment. By being placed under the umbrella of Roger Olofsson Bagge´s and Jan Lötvall´s group we have access to both fresh and froze tumor samples as well as to the state-of-the-art equipment for EV research. By isolating EVs derived from tumor tissues, we aim at identifying the pathways by which cells in the tumor microenvironment communicate and how this contributes to tumor progression. The knowledge generated from this project will improve our basic understanding of cancer and will provide a platform for developing future therapies and diagnostics. 

Duties 

The work includes designing, planning, and performing research work aimed at studying the microenvironments in tumors using cellular and molecular methods, including different types of DNA, RNA and protein analyses, as well as work with flow cytometry, electron microscopy and advanced methods for the isolation and characterization of extracellular vesicles. A close collaboration will take place with our clinical laboratory to collect patient samples. The work will mainly be carried out at the Sahlgrenska Center for Cancer Research and Krefting Research Centre.

Eligibility 

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.    

Employment 

The employment is full time and temporary, two years with the possibility of one year's extension, and is placed at the Institute of Clinical Sciences, Surgery. Starting date; As agreed  

Application 

Please note that this is an abbreviated version of the advertisement. To view the full advertisement, please click on “Apply here” or visit the website of the University of Gothenburg: https://www.gu.se/jobba-hos-oss/lediga-anstallningar.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.