Postdoctoral Researcher M/W in Organic Chemistry: Design of photo-immolable nanomaterials

The final goal of this research project is to develop self-immolable nanomaterials by light stimulation. During the current 1st phase of this project, the recruited postdoctoral fellow will synthesize model scaffolds that are suitable for such photodegradable reactions. This will involve the association of fragmentation reactions with specific photo-induced leaving groups. A methodological approach will be used in order to identify the optimum conditions necessary for such a reactivity pattern.
The identification of a light-induced self-degradable chemical pattern during this phase of the project will allow its future incorporation: (1) in polymers, for the design of new generations of light-degradable materials and (2) in phospholipids, for the design of stimuli-controlled drug-delivery systems.

- multi-step organic synthesis (Michel additions, heterocyclic chemistry, organometallic chemistry, orthogonal protective groups, fluorophores, etc.)
- analytical characterization of the synthesized chemicals: NMR, MS, IR, UV/Vis, Fluorescence spectroscopy, HPLC)
- bibliography
- regular reports and work-in-progress meetings in English
- article writing

This project is financially supported by the Emergence Call 2024 of the National Institute of Chemistry (INC) – CNRS, France.

Host institution: CBMN (Institute of Chemistry and Biology of Membranes and Nano objects) in Bordeaux, web: http://www.cbmn.u-bordeaux.fr
Team: MMB (Molecular Modeling and Bioengineering), supervisor Dr. Edouard Badarau, web: http://www.cbmn.u-bordeaux.fr/28-chimie-biophysique-modelisation-de-bio…

Working place: Bordeaux – France