Research Fellow (Pharmacy)

Job Description

The laboratory of A/Prof Victor Yu at the National University of Singapore (NUS) is currently recruiting a (Postdoctoral) Research Fellow. 

We are seeking for a motivated post-doctoral fellow to work on funded research project aimed at deciphering the roles of MOAP-1 in cellular senescence and ageing-associated disorders in liver. Long term goal of the project is to gain novel insights towards developing viable approaches for mitigating development and progression of NAFLD-associated liver diseases including NASH and HCC.

Successful candidate will have the opportunity to work with a multidisciplinary team as well as collaborators in Singapore and overseas.  

To facilitate a better understanding of the work being pursued in the laboratory, prospective applicants can refer to the following papers published by the lab: 

1. K.O. Tan et al., MAP-1 is a mitochondrial effector of Bax, (Track II), Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005. (https://doi.org/10.1073/pnas.0503524102)
2. N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, (Track II), Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007. (https://doi.org/10.1073/pnas.0700007104)
3. N.Y. Fu et al., Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism, Molecular Cell, 33: 15-29, 2009. (https://doi.org/10.1016/j.molcel.2008.11.025)
4. S.K. Sukumaran et al., A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010. (https://doi.org/10.1016/j.molcel.2010.02.015
5. C.T. Tan et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria, Cell Reports, 16:174-85, 2016.  (https://doi.org/10.1016/j.celrep.2016.05.068)
6. C.T. Tan et al., MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling, EMBO Reports, 22: e50854, 2021. (Featured as the cover story in Jan, 2021 issue: https://doi.org/10.15252/embr.202050854) 
7. H.C. Chang et al., The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore, Autophagy, 2021. (https://doi.org/10.1080/15548627.2021.1896157)
8. C.T. Tan, N.J.H. Soh, H.C. Chang and V.C Yu, p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities. FEBS J, 290: 892-912, 2023. (https://doi.org/10.1111/febs.16317)

Responsibilities include:

• Planning and execution of experiments 
• Guiding and working with junior staffs including students
• Participation in preparation of manuscripts and other reports
• Uphold research integrity and ensure safety compliance 
• Interested candidates please submit a detailed curriculum vitae, contact information of 4 referees and indicating your earliest availability.

Please note that only shortlisted candidates will be notified.

Qualifications Qualifications / Discipline:

Skills:

• Ph.D. degree in Molecular Biology, Biochemistry, Cancer biology or other related fields is preferred.
• Good communication skills and a team player.
• Effective oral and written management communication skills.
• Ability to work in a fast-paced environment.
• Other desirable attributes: self-motivated, organized, meticulous, efficient, and flexible.

Experience:

• Applicants with research experiences in mouse models and/or molecular and cell biology techniques (e.g., primary cell preparations, CRISPR-Cas9 gene editing, confocal microscopy, FACS, histology, IHC, IF or protein-protein interaction) are preferred.

More Information

Location: Kent Ridge Campus
Organization: Science
Department : Pharmacy
Job requisition ID : 21888