Job Information
- Organisation/Company
- University College Dublin
- Department
- Science
- Research Field
- Biological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Country
- Ireland
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Hours Per Week
- 40
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- HE / MSCA
- Marie Curie Grant Agreement Number
- 101120151
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
Project CLEXM provides a unique and exciting opportunity for early career researchers to apply correlative multimodal imaging (CMI) in a collaborative way to address a number of problems in health and disease. The projects available aim to provide a more complete view of the processes of disease and drug therapy by creating a composite view of the sample with multidimensional information about its macro-, meso- and microscopic structure, dynamics, function and chemical composition. CMI is the only approach to understand biomedical processes and diseases mechanistically and holistically.
CLEXM brings together a consortium of experts in Cell Imaging, Imaging Instrument Development and Disease/Therapeutic Research, who will each directly supervise the research projects of one or more PhD candidates, train researchers and disseminate correlative workflows and their applications. All of the projects will be complementary in terms of coupled imaging modality and will address specific correlative techniques of the overarching Doctoral Network project proposal. Each individual PhD candidate will benefit from networking with, and secondment to, other project partners in order to gain understanding and access knowledge from other complementary imaging techniques.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Bachelor Degree or equivalent
- Research Field
- Computer science » Other
- Education Level
- Bachelor Degree or equivalent
- All candidates would be expected to have strong communication skills and be prepared to adopt a collaborative approach to the work programmes. They should also be competent in the use of the English language and have good time management skills.
- Project 1: (ALBA/CSIC) Using correlative cryo-SXT and cryo-SIM imaging to study cells infected with West Nile Virus and Hepatitis C virus.
- Candidate should hold a Master of Science or equivalent degree in Physics, Biology, Chemistry or a related discipline.
- The candidate should have experience or interest in fluorescence microscopy, image analysis and structural biology.
- The ideal candidate should have a strong dedication to understanding biological questions at a cellular level and enjoy developing new experimental approaches.
- Project 2: (Aalen University)Developing Super-resolution cryo-fluorescence microscopy and its correlative combination with Cryo-focused ion beam scanning electron microscopy and soft x-ray microscopy as an innovative tool in biomedical research and diagnostics.
- The PhD candidate should hold M.Sc. in Physics, Engineering, Biophysics, or Informatics
- Experience in applying and developing novel microscopy methods in life sciences
- Experience in image analysis and hardware control
- Strong interest in interdisciplinary sciences and driving & automating method development (both hard- & software) to tackle biomedical research
- Proactive, analytical and creative mindset
- Preferred Qualification: Experience in cryogenic microscopies or correlative light and electron microscopy
Project 3: (Heidelberg University) Correlative super-resolution light and X-ray microscopy to probe genome organisation.
- The candidate should hold M.Sc. in Physics, Engineering, Biophysics, Cell or Molecular Biology or related disciplines.
- The candidate must have an interest in imaging techniques and a technical acumen.
- Experience in handling microscopes.
- Experience in data analysis or programming using MATLAB/Python/R.
Project 4: (Institut Pasteur) Intracellular niche formation of Shigella
- The candidate should have skills in infection biology, particularly with respect to intracellular bacteria.
- The candidate should hold B.Sc. in Biophysics, Cell or Molecular Biology or related disciplines.
- Some knowledge of imaging, as well as biophysics, would be beneficial.
- Willingness to learn advanced imaging techniques.
Project 5: (Soleil Synchrotron) Development of correlative multimodal imaging using hard-soft-X-ray-and-uv-synchrotron-radiation for structural cell biology at the Mesoscale
- The candidate should hold an M.Sc. or equivalent degree in Physics, Biology, Chemistry or a related discipline.
- Knowledge of microscopy, cell and/or tissue imaging, biological sample preparation methods and associated data analysis and exploitation.
- Experience in micro-fluidics, micro-fabrication and associated experimental environments.
- Previous experience in cryogenics would be an advantage.
Project 6: (SiriusXT) Image integration and analysis
- The candidate should hold B.Sc. degree in Computer Science or Bioinformatics with experience in using AI and other techniques for image analysis. Ideally a Master's degree (or equivalent) in Bioinformatics or Computer Science.
- Knowledge of microscopy will be considered an advantage.
- Knowledge of image acquisition and data handling in microscopy.
- Experience in preparation and handling biological specimens for imaging, particularly for soft X-ray cryo-tomography or cryo-electron microscopy, will be considered an advantage.
- Proficiency in Python
- Experience in developing and implementing software algorithms for image processing and analysis is an advantage.
- Strong written and verbal communication skills for effectively documenting research findings and presenting results to scientific audiences.
- Ability to work both independently and collaboratively as part of a research team.
- Willingness to learn and adapt to new technologies and methodologies.
- Knowledge of X-ray imaging and tomography techniques.
- Familiarity with deep learning frameworks (e.g., TensorFlow, PyTorch) for developing and training neural networks and applying them to image analysis tasks
- Knowledge of image registration techniques and algorithms.
- Understanding of computer vision concepts and techniques for object classification and semantic segmentation.
- Experience in scientific writing, including preparing manuscripts and conference presentations.
Project 7: (University College Dublin) Tracking the delivery of nanoparticles into cells
- Candidates should have a B.Sc. in Cell Biology or a related discipline.
- Prior expertise with fluorescence imaging and/or electron microscopy would be an advantage.
- Prior experience in working with nanomaterials would be an advantage.
Project 8: (University College Dublin) Correlative SXT and super-resolution imaging to investigate cilia disease mechanisms in an animal model
- Candidates should have a B.Sc. in Cell Biology or a similar discipline area and have a passion for microscopy.
Project 9: (Institut Pasteur) In situ imaging of the protein complex Usher 2 involved in hearing and vision
- The CLEXM candidate should have a solid basis in protein chemistry, cell biology, biophysics or related fields
- The candidate should hold B.Sc. in Biophysics, Cell or Molecular Biology or related disciplines.
- Previous hands-on experience in EM and/or cryo-EM will be highly appreciated.
- A genuine enthusiasm for advanced microscopy techniques, image analysis and for methods development at the cellular level will be essential for the success of the project.
- Languages
- ENGLISH
- Level
- Good
Additional Information
The EU provides support for each recruited researcher in the form of
- living allowances, indexed to the cost of living in the country where the Doctoral Candidates will be hosted, is paid on a monthly basis. This can vary from approx. €112,000 (Spain) to approx. €146,000 (Ireland) for the full duration of the PhD.
- mobility allowances.
- if applicable, family, long-term leave and special needs allowances.
Supported researchers must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment. Candidates should comply with the mobility rules: in general, they must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting organisation for more than 12 months in the 36 months immediately before their recruitment date. Candidates can be of any nationality.
All applications proceed first through the online recruitment portal on the Clexm.eu website. Candidates can apply electronically with their CV, cover letter and transcripts as a single file. Shortlisted candidates may be invited for online interviews and, if selected may need to make a separate application to the University awarding the PhD degree, according to the requirements of that University.
More info about the CLEXM project as well as detailed candidate requirement can be found on the CLEXM project website, www.clexm.eu
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- ALBA Synchrotron
- Country
- Spain
- City
- Barcelona
- Street
- Carrer de la Llum, 2, 26, 08290 Cerdanyola del Vallès
- Geofield
- Number of offers available
- 1
- Company/Institute
- Aalen University
- Country
- Germany
- City
- Aalen
- Postal Code
- 73430
- Street
- Beethovenstraße 1
- Geofield
- Number of offers available
- 1
- Company/Institute
- COS, University of Heidelberg
- Country
- Germany
- City
- Heidelberg
- Postal Code
- 69117
- Street
- Grabengasse 1,
- Geofield
- Number of offers available
- 2
- Company/Institute
- Institut Pasteur
- Country
- France
- City
- Paris
- Postal Code
- 75015
- Street
- 25-28 Rue du Dr Roux
- Geofield
- Number of offers available
- 1
- Company/Institute
- Soleil Synchrotron
- Country
- France
- City
- Saint-Aubin, Paris
- Postal Code
- 91190
- Street
- L'Orme des Merisiers
- Geofield
- Number of offers available
- 1
- Company/Institute
- SiriusXT
- Country
- Ireland
- City
- DUBLIN
- Postal Code
- A94XY47
- Street
- 9A Holly Avenue
- Geofield
- Number of offers available
- 2
- Company/Institute
- University College Dublin
- Country
- Ireland
- City
- Dublin
- Postal Code
- 4
- Street
- Belfield
- Geofield
Where to apply
- Website
Contact
- State/Province
- Co. Dublin
- City
- Dublin
- Street
- Belfield
- Postal Code
- 4
- info@clexm.eu