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EURAXESS

3-YEAR POSTDOC POSITION STUDYING CELLULAR SENESCENCE AND AGEING

Center for Biological Research "Margarita Salas"-CSIC
1 Jun 2023

Job Information

Organisation/Company
Center for Biological Research "Margarita Salas"-CSIC
Department
Funding & Resources Unit
Research Field
Biological sciences
Researcher Profile
Recognised Researcher (R2)
Country
Spain
Application Deadline
Type of Contract
Permanent
Job Status
Full-time
Hours Per Week
37,5
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

A postdoctoral contract is offered in the research group "Epigenetics and Cellular Senescence Lab" at the Center for Biological Research (CSIC) in Madrid. The contract will be carried out through the CSIC and will be charged to the project of the State Research Agency (Project PID2021-125656OB financed by MCIN/AEI/ 10.13039/501100011033/FEDER,UE).

Aging is a process of cellular and tissue dysfunction, which presents several characteristics, such as the activation of cellular senescence. Senescence is a process by which cells stop proliferating and produce a particular secretome. Our laboratory has recently identified that small extracellular vesicles (sEVs) serve as a cellular communication mechanism between senescent cells and proliferating cells. In this project, we propose to study the metabolomic changes produced during aging in human cells and in mouse tissues. For them, metabolomics, gene editing (CRISPR/Cas), proteomics and single-cell RNA sequencing (scRNAseq) studies will be carried out.

 

Requirements

Research Field
Biological sciences » Biology
Education Level
PhD or equivalent
Skills/Qualifications

For this, we are looking for a highly motivated person, capable of working independently, but also in a team. Experience in some of the following techniques will be valued, although it is not an essential requirement: use of primary cultures, infections with lentiviruses and/or retroviruses, isolation of extracellular vesicles and/or work with experimental animals. The scientific trajectory will also be valued, being beneficial to have a publication or paper under review by the first author.

Recent group posts:

1. Fafián-Labora J, ... O'Loghlen A. (2020) Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. Cell Metabolism 32(1):71-86.e5. Research highlight in Nat Rev Mol Cell Biol. Selected in “Focus in Aging” issue (Cell Metabolism).

2. Fafián-Labora J and O'Loghlen, A.* (2020) Classical and Nonclassical Intercellular Communication in Senescence and Aging. Trends in Cell Biology 30(8):628-39

 

3. Borghesan M, ... O'Loghlen, A*. Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence. 2019; Cell Reports 27, 3956–3971

 

Languages
ENGLISH
Level
Good
Research Field
Biological sciences » Biology

Additional Information

Benefits

The Center for Biological Research (CIB) is one of the most prestigious and historical research centers of the Spanish National Research Council (CSIC). Generations of distinguished scientists have carried out their research since the Center’s foundation in 1953, and new scientists continue to be trained there. In 2019, in homage to one of the most important researchers in the history of the CIB, where she spent a total of 13 years, and of Spanish molecular biology, the CIB was renamed the Margarita Salas Center for Biological Research.

Currently, the CIB Margarita Salas is reorganizing into three research programs, in which researchers study the structure and organization of living matter and its processes, seek to understand the bases of disease and discover experimental treatments and develop biotechnological processes to enable sustainable growth and facilitate agricultural production. We combine the generation of new knowledge with the development of applications that can help solve current and future challenges facing society.

Work Location(s)

Number of offers available
1
Company/Institute
Spanish National Research Centre (CSIC - CIB)
Country
Spain
State/Province
Madrid
City
Madrid
Postal Code
28040
Street
Calle Ramiro de Maeztu 9

Where to apply

E-mail
ana.ologhlen@cib.csic.es

Contact

State/Province
Madrid
City
Madrid
Website
Street
9th Ramiro de Maeztu,
Postal Code
28040
E-Mail
ana.ologhlen@cib.csic.es