PhD position: Investigation of the mechanisms linking CAIX-related hypoxic tumor microenvironment and obesity to pancreatic cancer progression in relation to immune response

Department of Cancer Biology of the Biomedical Research Center of the Slovak Academy of Sciences offers a four year doctoral study on the PhD thesis: "Investigation of the mechanisms linking CAIX-related hypoxic tumor microenvironment and obesity to pancreatic cancer progression in relation to immune response".

Supervisor: Mgr. Eliška Švastová, PhD.

Annotation:

The topic is focused on:

- the influence of CAIX expression and function on molecular cross-talk in tumor stroma among tumor cells, fibroblasts, adipocytes and immune cells with respect to its role in creating acidic and pro-invasive tumor microenvironment, and to investigate the impact of CAIX-related hypoxic/acidic TME on pro-tumorigenic environment in pancreatic cancer models

- the effect of CAIX expression and its inhibition on immune cell infiltration and macrophage differentiation in 3D spheroids

- the effect of adipokines on the progression of pancreatic tumor cells in relation to hypoxia and CAIX expression

Keywords: hypoxia, CAIX, pancreatic ductal adenocarcinoma, obesity, immune response

This PhD position is opened in collaboration with the Faculty of Medicine, Comenius University in Bratislava, in the study programme "oncology" and for school year 2023/2024.

The admission procedure is therefore managed by the Faculty of Medicine, Comenius University in Bratislava.For all instructions see here

Before submitting an application, pleasecontact the supervisor for further information and procedures (email: eliska.svastova@savba.sk).