Postdoc Center for Proteomics and Metabolomics

As a postdoc you will investigate intestinal glycans in inflammatory diseases by mass spectrometry imaging. In the multidisciplinary GlycanTrigger project, we aim to gain new molecular insights in the transition from healthy to chronic inflammation in patients with IBD. A specific focus lies on the changes in glycosylation of specific cell types involved in this transition. To accurately study the role of protein and lipid glycosylation at the single-cell level, new methods need to be developed that allow spatial and in-depth characterization of glycosylated molecules. You will develop on-tissue mass spectrometry imaging (MSI) methods for in-situ N-, O- and lipid-glycan analysis. The in-situ methods need to be complemented with off-tissue analyses with sufficient analytical sensitivity and depth-of-coverage, e.g. LC-MS-based methods. Ultimately, developed methods will be applied to a well-defined cohort of IBD patients to get insight into the role of glycosylation in IBD. This will be done in collaboration with both local clinicians and international partners from the GlycanTrigger consortium.